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자료유형
학술저널
저자정보
Choi, Yoori (Department of Nuclear Medicine, College of Medicine, Seoul National University) Ha, Seunggyun (Department of Nuclear Medicine, College of Medicine, Seoul National University) Lee, Yun-Sang (Department of Nuclear Medicine, College of Medicine, Seoul National University) Kim, Yun Kyung (Institute of Brain Science, Korean Institute of Science and Technology) Lee, Dong Soo (Department of Nuclear Medicine, College of Medicine, Seoul National University) Kim, Dong Jin (Institute of Brain Science, Korean Institute of Science and Technology)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제52권 제1호
발행연도
2018.1
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24 - 30 (7page)

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The pathological features of Alzheimer's disease are senile plaques which are aggregates of ${\beta}$-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and these induce various other neurodegenerative diseases, such as progressive supranuclear palsy, corticobasal degeneration, frontotemporal lobar degeneration, frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and chronic traumatic encephalopathy. In the case of Alzheimer's disease, the measurement of neurofibrillary tangles associated with cognitive decline is suitable for differential diagnosis, disease progression assessment, and to monitor the effects of therapeutic treatment. This review discusses considerations for the development of tau ligands for imaging and summarizes the results of the first-in-human and preclinical studies of the tau tracers that have been developed thus far. The development of tau ligands for imaging studies will be helpful for differential diagnosis and for the development of therapeutic treatments for tauopathies including Alzheimer's disease.

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