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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 108 - 117 (10page)
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Amyloid and tau protein abnormalities have been identified as the main causes of Alzheimer’s disease but exact mechanisms remain to be revealed. Especially, amyloid beta and tau protein coupling and neuroinflammatory and neurovascular contributions to Alzheimer disease are quite mysterious. Many animal models and basic biological research are trying to solve these puzzles. Known as aging processes, autophagy, mitochondrial degeneration with generation of reactive oxygen species, and age-related epigenetic modifications are also known to be associated with development of Alzheimer’s disease. Environmental factors such as bacterial and viral infections, heavy metal ions, diet, sleep, stress, and gut microbiota are also risk factors of Alzheimer’s disease. Future development of preventive and therapeutic modalities may be dependent on the pathobiology of Alzheimer’s disease.
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참고문헌 (90)
참고문헌 신청
United Nations / 2019 / World population ageing 2019 :5~22
Patterson C / 2018 / World Alzheimer Report 2018. The state of the art of dementia research: new frontiers
What is dementia?
Lauter H / 1968 / On the clinical study and psychopathology of Alzheimer’s disease. Demonstration of 203 pathologically-anatomically verified cases / Psychiatr Clin (Basel) 1:85~108
Terry RD / 1991 / Physical basis of cognitive alterations in Alzheimer’s disease : synapse loss is the major correlate of cognitive impairment / Ann Neurol 30:572~580
Patterson C / 2018 / World Alzheimer Report 2018. The state of the art of dementia research: new frontiers
What is dementia?
Lauter H / 1968 / On the clinical study and psychopathology of Alzheimer’s disease. Demonstration of 203 pathologically-anatomically verified cases / Psychiatr Clin (Basel) 1:85~108
Terry RD / 1991 / Physical basis of cognitive alterations in Alzheimer’s disease : synapse loss is the major correlate of cognitive impairment / Ann Neurol 30:572~580
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