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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제7호
- 발행연도
- 2008.1
- 수록면
- 886 - 890 (5page)
이용수
초록· 키워드
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A methanol extract of Sophora japonica was subjected to anti-platelet activity guided fractionation affording the isolation of four flavonoids and six flavonoid-glycosides: biochanin A (1), irisolidone (2), genistein (3), sissotrin (4), sophorabioside (5), genistin (6), tectoridin (7), apigenin (8), quercitrin (9), and rutin (10). The structure of each compound was determined by a variety of spectroscopic methods. Among the compounds, 1, 3, and 7 showed ${\sim}2.5-6.5$ fold greater inhibitory effects on arachidonic acid (AA) and U46619 induced platelet aggregation ($IC_{50}$: 19.9 and $99.8\;{\mu}M$; 20.3 and $53.8\;{\mu}M$; 25.9 and $123.4\;{\mu}M$, respectively) than acetylsalicylic acid (ASA, $IC_{50}$: 63.0 and $350.0\;{\mu}M$). Compound 2 was an ${\sim}22-40$ fold stronger inhibitor than ASA on AA and U46619 induced aggregation ($IC_{50}$: 1.6 and $15.6\;{\mu}M$, respectively).
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