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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Objectives: This study was performed to identify the anti-inflammatory effect of Pulsatilla koreana (PK) methanol extract on lipopolysaccharide (LPS) induced inflammatory. Methods: There were five groups. They were control group, LPS-exposed PK methanol extract group ($0{\mu}g/ml$, $10{\mu}g/ml$, $30{\mu}g/ml$, $100{\mu}g/ml$). To measure out cytotoxicity of PK, we performed the MTT assay. To evaluate the anti-inflammatory effect of PK, we examined the inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), and pro-inflammatory cytokines (interleukin $[IL]-1{\beta}$, IL-6, tumor necrosis $factor-{\alpha}$ [$TNF-{\alpha}$], IL-10). Results: 1. The extract of PK (${\sim}100{\mu}g/ml$) itself did not have any cytotoxic effect in RAW 264.7 cells. 2. The concentration of plasma NO and PGE2 in PK methanol extract group showed a lower values than those of control group. 3. The concentration of plasma $IL-1{\beta}$, plasma IL-6, and plasma $TNF-{\alpha}$ in PK methanol extract group showed a lower values than those of control group. 4. The concentration of Plasma IL-10 in PK methanol extract groups showed higher than control group; however, these values showed no significantly different. Conclusions: According to this study, the extract of PK could be used as a protective agent against inflammation.
목차
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참고문헌 (49)
참고문헌 신청
Abbas A / 2007 / Cellular andmolecular immunology / Elsevier Saunders :355
Boumpas DT / 1993 / Glucocorticoid therapy of immune-mediated diseases: basic and clinical correlates / Ann Intern Med 119(12):1198~1208
Kim TH / 1991 / Effect of Ehedrae herba on the immune response in mice / Korean J Pharmacogn 22(3):183~191
이은 / 2007 / Anti-inflammatory Effect of Scutellariae Radix / 한국자원식물학회지 20(6):546~552
남정연 / 2005 / 감국에서 분리한 Kikkanol F Monoacetate와 5-Hydroxy-6,7,3',4'- tetramethoxyflavone의 IL-6 생성억제활성 / 생약학회지 36(3):186~190
Boumpas DT / 1993 / Glucocorticoid therapy of immune-mediated diseases: basic and clinical correlates / Ann Intern Med 119(12):1198~1208
Kim TH / 1991 / Effect of Ehedrae herba on the immune response in mice / Korean J Pharmacogn 22(3):183~191
이은 / 2007 / Anti-inflammatory Effect of Scutellariae Radix / 한국자원식물학회지 20(6):546~552
남정연 / 2005 / 감국에서 분리한 Kikkanol F Monoacetate와 5-Hydroxy-6,7,3',4'- tetramethoxyflavone의 IL-6 생성억제활성 / 생약학회지 36(3):186~190
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