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자료유형
학술저널
저자정보
Ota, Miho (Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry) Ogura, Jun (Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry) Ogawa, Shintaro (Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry) Kato, Koichi (Organic Radiochemistry Section, Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center Hospital of Neurology and Psychiatry) Matsuda, Hiroshi (Integrative Brain Imaging Center, National Center Hospital of Neurology and Psychiatry) Kunugi, Hiroshi (Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제52권 제3호
발행연도
2018.1
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224 - 228 (5page)

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Purpose Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods Ten adult male Fischer F344 rats underwent [$^{11}C$]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [$^{11}C$]PK11195 between before and after injection was determined. Results There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [$^{11}C$]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [$^{11}C$]PK11195 PET would clarify the relationships between neuroinflammation and depression.

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