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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 73 - 80 (8page)
이용수
초록· 키워드
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ObjectiveaaThe present study explored the three-dimensional spatial arrangements of the neurons and glial cells within the medial prefrontal cortex (mPFC) of rats.
MethodsaaIt evaluated the arrangement for differences after stress with or without treatment with curcumin and sertraline using second-order stereology. Orientator method was applied to obtain isotropic uniform random sections of mPFC. The pair correlation g(r) and cross-correlation functions were estimated by counting dipole probes superimposed on histological sections of mPFC.
ResultsaaThe mean total volume of neurons and glial cells was 0.80 (0.05) and 0.40 (0.07), respectively in the control group. The corresponding values decreased by 50% in the stressed group. The curve of g(r) for the neurons and glial cells showed a wider gap between the stressed rats’ mPFC. Theses indicate a negative correlation (repulsion) between the neurons and glial cells in the stressed rats. Evaluation of the cross-correlation function of the neurons and glial cells also showed a negative correlation in the stressed group. The estimated values of the global degree of order in the spatial point pattern for neurons and glial cells were 0.62 and 0.20 in control and stressed animals, respectively. Curcumin and sertraline protected the spatial arrangements of the cells after stress induction in rats. In addition, the volume of the neurons and glial cells remained unchanged after stress.
ConclusionaaDissociation of the neurons and glial cells can is seen at some places in the stressed rats’ cortex. However, the spatial arrangement of the cells was remained unchanged in curcumin+stress and sertraline+stress rats.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Mattfeldt T / 2006 / Statistical analysis of reduced pair correlation functions of capillaries in the prostate gland / J Microsc 223:107~119
Mattfeldt T / 1993 / Second-order stereology of benign and malignant alterations of the human mammary gland / J Microsc 171:143~151
Noorafshan A / 2011 / Effects of curcumin on the dorsal root ganglion structure and functional recovery after sciatic nerve crush in rat / Micron 42:449~455
Hof PR / 2003 / Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia / Biol Psychiatry 53:1075~1085
Bachis A1 / 2008 / Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex / Neurosci Lett 442:104~108
Mattfeldt T / 1993 / Second-order stereology of benign and malignant alterations of the human mammary gland / J Microsc 171:143~151
Noorafshan A / 2011 / Effects of curcumin on the dorsal root ganglion structure and functional recovery after sciatic nerve crush in rat / Micron 42:449~455
Hof PR / 2003 / Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia / Biol Psychiatry 53:1075~1085
Bachis A1 / 2008 / Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex / Neurosci Lett 442:104~108
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