지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
In the past decade, structural, molecular, and functional changes in glial cells have become a major focus in the search for the neurobiological foundations of schizophrenia. Glial cells, consisting of oligodendrocytes, astrocytes, microglia, and nerve/glial antigen 2-positive cells, constitute a major cell population in the central nervous system. There is accumulating evidence of reduced numbers of oligodendrocytes and altered expression of myelin/oligodendrocyte-related genes that might explain the white matter abnormalities and altered inter- and intra-hemispheric connectivities that are characteristic signs of schizophrenia. Astrocytes play a key role in the synaptic metabolism of neurotransmitters ; thus, astrocyte dysfunction may contribute to certain aspects of altered neurotransmission in schizophrenia. Increased densities of microglial cells and aberrant expression of microglia-related surface markers in schizophrenia suggest that immunological/inflammatory factors are of considerable relevance to the pathophysiology of psychosis. This review describes current evidence for the multifaceted role of glial cells in schizophrenia and discusses efforts to develop glia-directed therapies for the treatment of the disease.
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참고문헌 (67)
참고문헌 신청
Graeber MB / 2010 / Changing face of microglia / Science 330:783~788
Nishiyama A / 2009 / Polydendrocytes (NG2cells): multifunctional cells with lineage plasticity / Nat Rev Neurosci 10:9~22
Kubicki M / 2005 / Evidence for white matter abnormalities in schizophrenia / Curr Opin Psychiatry 18:121~134
Rubinov M / 2013 / Schizophrenia and abnormal brain network hubs / Dialogues Clin Neurosci 15:339~349
Konrad A / 2008 / Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon? / Schizophr Bull 34:72~92
Nishiyama A / 2009 / Polydendrocytes (NG2cells): multifunctional cells with lineage plasticity / Nat Rev Neurosci 10:9~22
Kubicki M / 2005 / Evidence for white matter abnormalities in schizophrenia / Curr Opin Psychiatry 18:121~134
Rubinov M / 2013 / Schizophrenia and abnormal brain network hubs / Dialogues Clin Neurosci 15:339~349
Konrad A / 2008 / Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon? / Schizophr Bull 34:72~92
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