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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 2 - 10 (9page)
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초록· 키워드
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Objective: Astrocyte dysfunctions are related to several central nervous system (CNS)pathologies. Transcriptomic profling of human mRNAs to investigate astrocyte functions mayprovide the basic molecular-biological data pertaining to the cellular activities of astrocytes. Methods: Human Primary astrocytes (HPAs) and human neural stem cell line (HB1.F3)were used for differential digital gene analysis. In this study, a massively parallel sequencingplatform, next-generation sequencing (NGS), was used to obtain the digital gene data from HPAs. A comparative analysis of the DGE from HPA and HB1.F3 cells wasperformed. Sequencing was performed using NGS platform, and subsequently, bioinformaticanalyses were implemented to reveal the identity of the pathways, relatively up- or downregulated in HPA cells. Results: The top, novel canonical pathways up-regulated in HPA cells than in the HB1. F3 cells were “Cyclins and cell cycle regulation,” “Integrin signaling,” “Regulation of eIF4and p70S6K signaling,” “Wnt/β-catenin signaling,” “mTOR signaling,” “Aryl hydrocarbonreceptor signaling,” “Hippo signaling,” “RhoA signaling,” “Signaling by Rho familyGTPases,” and “Glioma signaling” pathways. The down-regulated pathways were “Cell cycle:G1/S checkpoint regulation,” “eIF2 signaling,” “Cell cycle: G2/M DNA damage checkpointregulation,” “Telomerase signaling,” “RhoGDI signaling,” “NRF2-mediated oxidative stressresponse,” “ERK/MAPK signaling,” “ATM signaling,” “Pancreatic adenocarcinoma signaling,”“VEGF signaling,” and “Role of CHK proteins in cell cycle checkpoint control” pathways. Conclusion: This study would be a good reference to understand astrocyte functions at themolecular level, and to develop a diagnostic test, based on the DGE pattern of astrocytes, as apowerful, new clinical tool in many CNS diseases.
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참고문헌 (32)
참고문헌 신청
Abbott NJ / 2006 / Astrocyte-endothelial interactions at the blood-brain barrier / Nat Rev Neurosci 7:41~53
Anders S / 2013 / Count-based differential expression analysis of RNA sequencing data using R and Bioconductor / Nat Protoc 8:1765~1786
Banerjee S / 2011 / Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner / Proc Natl Acad Sci U S A 108:15996~16001
Benarroch EE / 2005 / Neuron-astrocyte interactions : partnership for normal function and disease in the central nervous system / Mayo Clin Proc 80:1326~1338
Brenner S / 2000 / Gene expression analysis by massively parallel signature sequencing(MPSS)on microbead arrays / Nat Biotechnol 18:630~634
Anders S / 2013 / Count-based differential expression analysis of RNA sequencing data using R and Bioconductor / Nat Protoc 8:1765~1786
Banerjee S / 2011 / Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner / Proc Natl Acad Sci U S A 108:15996~16001
Benarroch EE / 2005 / Neuron-astrocyte interactions : partnership for normal function and disease in the central nervous system / Mayo Clin Proc 80:1326~1338
Brenner S / 2000 / Gene expression analysis by massively parallel signature sequencing(MPSS)on microbead arrays / Nat Biotechnol 18:630~634
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