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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 33 - 39 (7page)
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Oxidative stress activates several intracellular signaling cascades that may have deleterious effects on neuronal cell survival. Thus, controlling oxidative stress has been suggested as an important strategy for prevention and/or treatment of neurodegenerative diseases. In this study, we found that ginsenoside Rh1 inhibited hydrogen peroxide-induced reactive oxygen species generation and subsequent cell death in rat primary astrocytes. Rh1 increased the expression of phase II antioxidant enzymes, such as heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1, superoxide dismutase-2, and catalase, that are under the control of Nrf2/ARE signaling pathways. Further mechanistic studies showed that Rh1 increased the nuclear translocation and DNA binding of Nrf2 and c-Jun to the antioxidant response element (ARE), and increased the ARE-mediated transcription activities in rat primary astrocytes. Analysis of signaling pathways revealed that MAP kinases are important in HO-1 expression, and act by modulating ARE-mediated transcriptional activity. Therefore, the upregulation of antioxidant enzymes by Rh1 may provide preventive therapeutic potential for various neurodegenerative diseases that are associated with oxidative stress.
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참고문헌 (28)
참고문헌 신청
Alam, J / 2007 / How many transcription factors does it take to turn on the heme oxygenase-1 gene? / Am. J. Respir. Cell Mol. Biol 36:166~174
Cheng, Y / 2005 / Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action / Acta Pharmacol. Sin 26:143~149
Dallerac, G / 2013 / How do astrocytes shape synaptic transmission? Insights from electrophysiology / Front. Cell. Neurosci 7:159
Hou, J / 2014 / Long-term administration of Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus / Int. J. Mol. Med 33:234~240
Jaiswal, A. K / 2004 / Nrf2 signaling in coordinated activation of antioxidant gene expression / Free Rad. Biol. Med 36:1199~1207
Cheng, Y / 2005 / Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action / Acta Pharmacol. Sin 26:143~149
Dallerac, G / 2013 / How do astrocytes shape synaptic transmission? Insights from electrophysiology / Front. Cell. Neurosci 7:159
Hou, J / 2014 / Long-term administration of Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus / Int. J. Mol. Med 33:234~240
Jaiswal, A. K / 2004 / Nrf2 signaling in coordinated activation of antioxidant gene expression / Free Rad. Biol. Med 36:1199~1207
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