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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The rhesus (Rh) blood group system is one of the most important systems in transfusion medicine. Rh alloantibodies can cause hemolytic transfusion reactions and difficulties in finding compatible blood. On the other hand, the phenotypic test and pre-transfusion compatibilization for RhCE antigens have not been routinely performed in most clinical laboratories. This study examined the occurrence of Rh alloimmunization, including C, c, E, and e antigens, after Rh incompatible red cell transfusion during a specific period. From November 2016 to December 2017, clinical and laboratory information of transfused patients was collected; this included the transfusion history and Rh phenotypes of the patients and transfused red blood cell (RBC) products. Of 3,623 patients who received red cell transfusion, 99 (2.8%) revealed unexpected antibodies. Among them, 48 patients (48.5%) had alloantibodies to the Rh-system antigen, including the anti-D antibody. Based on the transfusion history and Rh phenotypes of patients and transfused packed RBCs, 11 patients (11.1%) were assumed to develop Rh alloantibodies after discrepant Rh phenotype red cell transfusion. A considerable proportion of unexpected antibodies was caused by the exposure of Rh mismatched red cells. Therefore, extended Rh antigen matching, including the C, c, E, and e, is needed to prevent alloimmunization. (Korean J Blood Transfus 2020;31:247-253)
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참고문헌 (15)
참고문헌 신청
김신영 / 2009 / 적혈구 비예기항체 빈도 및 분포의 산출기준에 따른 결과값 비교 / Annals of Laboratory Medicine 29(2):152~157
신정원 / 2013 / Unexpected red cell antibody detection by conditional combination of LISS/Coombs and NaCl/Enzyme gel tests at a tertiary care hospital in Korea: A 5-year study / Blood Research 48(3):217~221
Zalpuri S / 2012 / Red-bloodcell alloimmunization and number of red-bloodcell transfusions / Vox Sang 102:144~149
Lin Y / 2017 / Prophylactic RhCE and Kell antigen matching : impact on alloimmunization in transfusion-dependent patients with myelodysplastic syndromes / Vox Sang 112:79~86
Sachan D / 2015 / An acute hemolytic transfusion reaction due to the"anti-c"rhesus antibody : a case report emphasizing the role of transfusion medicine / Asian J Transfus Sci 9:213~215
신정원 / 2013 / Unexpected red cell antibody detection by conditional combination of LISS/Coombs and NaCl/Enzyme gel tests at a tertiary care hospital in Korea: A 5-year study / Blood Research 48(3):217~221
Zalpuri S / 2012 / Red-bloodcell alloimmunization and number of red-bloodcell transfusions / Vox Sang 102:144~149
Lin Y / 2017 / Prophylactic RhCE and Kell antigen matching : impact on alloimmunization in transfusion-dependent patients with myelodysplastic syndromes / Vox Sang 112:79~86
Sachan D / 2015 / An acute hemolytic transfusion reaction due to the"anti-c"rhesus antibody : a case report emphasizing the role of transfusion medicine / Asian J Transfus Sci 9:213~215
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