지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.1
- 수록면
- 27 - 31 (5page)
이용수
초록· 키워드
오류제보하기
The most common aging-related neurodegenerative disorder is Alzheimer’s disease (AD), of which the main symptom is memory disturbance. Though the mechanism of AD pathogenesis is not fully defined, abnormal aggregation of amyloid beta (Ab) plaques and tau have been considered as key factors and main histological hallmarks of the disease. Astrocyte is responsible for the control of cells and the environment around brain and spinal cord cells. Astrocytes have been implicated with AD. However, the exact function of astrocytes in AD has not been established. In this study, we investigated the regulation of astrocytes in the AD model using primary cultures. We have demonstrated that oligomerized Ab is toxic to neurons and can induce cell death in primary cultures. In the primary cultures containing neurons and astrocytes, amyloid beta uptake was observed in both neurons and astrocytes. To verify if the uptake of amyloid beta in astrocytes is dependent on neurons, we separated and cultured primary astrocytes with no neurons. Amyloid uptake was still observed in this pure astrocyte culture, suggesting that the uptake of amyloid beta is a neuron-independent function of astrocytes. Astrocyte activation was observed in both pure and mixed cultures. Taken together, our data suggest that astrocyte is activated by oligomerized Ab and uptakes it, which is independent of neurons.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Co-culture platform for neuron-astrocyte interaction using optogenetic modulation
Biomedical Engineering Letters (BMEL)
2022 .11
-
Up to Date on Astrocytes
International Neurourology Journal
2018 .01
-
Molecular Characterization of Primary Human Astrocytes Using Digital Gene Expression Analysis
Korean Journal of Neurotrauma
2019 .01
-
New Roles for Old Glue: Astrocyte Function in Synaptic Plasticity and Neurological Disorders
International Neurourology Journal
2018 .01
-
The role of astrocytes in the regulation of synaptic plasticity in chronic pain rats
한국실험동물학회 학술발표대회 논문집
2018 .01
-
LPS Sensing Mechanism of Human Astrocytes : Evidence of Functional TLR4 Expression and Requirement of Soluble CD14
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2017 .12
-
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
NOX4 deficiency lowers the neuronal differentiation and severely reduces the population of astrocytes in the hippocampus
한국실험동물학회 학술발표대회 논문집
2020 .07
-
GiD mouse: a novel animal model for reactive astrocytes and Alzheimer’s disease
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Changes of HCN channels in pyramidal neurons and their new expressions in pericytes and/or astrocytes in the gerbil hippocampal CA1 subfield after transient ischemia
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Neurotoxicity screening of insecticides based on Neuron/Astrocyte co-culture model and neurotoxic effect of pyrethroid insecticides
환경독성보건학회 심포지엄 및 학술대회
2022 .05
-
Parkinson’s disease progression revealed by astrocyte changes in a lewy body pathology–Induced non-human primate model (pilot study)
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Prophylactic role of Korean Red Ginseng in astrocytic mitochondrial biogenesis through HIF-1a
Journal of Ginseng Research
2022 .05
-
Development of a neurotoxicity screening system using SH-SY5Y and Astrocyte co-culture model
환경독성보건학회 심포지엄 및 학술대회
2022 .10
-
The Modulation of Neurotrophin and Epigenetic Regulators: Implication for Astrocyte Proliferation and Neuronal Cell Apoptosis After Spinal Cord Injury
Annals of Rehabilitation Medicine
2016 .01
-
New protocol for hemorrhage preserve using animal model of traumatic brain injury
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Korean Red Ginseng-induced astrocytic HIF-1α: A key regulator of neuroglobin derived from neural stem cell differentiation in physiologic retina and brain
Journal of Ginseng Research
2025 .03
-
RNase III enzyme Dicer regulates RIP3 to induce apoptosis in astrocytes
대한체질인류학회 학술대회 연제 초록
2019 .05
최근 본 자료
댓글(0)
0