지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objectives Oxidative stress, in which antioxidant proteins and scavenger protection are overwhelmed by reactive oxygen species (ROS) production, is recognized as one of central causes of disuse muscle atrophy. In this study, the hypothesis that oral treatment with Dangguibohyul-tang (Dangguibuxuetang) could attenuate immobilization-induced skeletal muscle atrophy was tested. Methods The hindlimb immobilization was performed with casting tape to keep the left ankle joint in a fully extended position. The Rats in Dangguibohyul-tang treated group (DGBHT) (n=10) were orally administrated Dangguibohyul-tang water extract, and rats of Control group (n=10) were given with saline only. After 2 weeks of immobilization, the morphology of right and left gastrocnemius muscles in both DGBHT and Control groups were assessed by hematoxylin and eosin staining. Results Dangguibohyul-tang water extract represented the significant protective effects against the reductions of the left gastrocnemius muscles weight and average cross section area to compared with Control group. Moreover, the treatment with Dangguibohyul-tang extract significantly enhanced the Cu/Zn-SOD activities in gastrocnemius muscle compared with Control group. Conclusions Thses results suggest that Dangguibohyul-tang has protective effects against immobilization-induced muscle atrophy by increasing the Cu/Zn-SOD activities in gastrocnemius muscle.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Metter EJ / 2002 / Skeletal muscle strength as a predictor of all-cause mortality in healthy men / J Gerontol A Biol Sci Med Sci 57(10):359~365
Wall BT / 2013 / Nutritional strategies to attenuate muscle disuse atrophy / Nutr Rev 71(4):195~208
Wall BT / 2013 / Skeletal muscle atrophy during short-term disuse : implications for age-related sarcopenia / Ageing Res Rev 12(4):898~906
Matsumoto Y / 2014 / The non-thermal effects of pulsed ultrasound irradiation on the development of disuse muscle atrophy in rat gastrocnemius muscle / Ultrasound Med Biol 40(7):1578~1586
Powers SK / 2012 / Mitochondrial signaling contributes to disuse muscle atrophy / Am J Physiol Endocrinol Metab 303(1):31~39
Wall BT / 2013 / Nutritional strategies to attenuate muscle disuse atrophy / Nutr Rev 71(4):195~208
Wall BT / 2013 / Skeletal muscle atrophy during short-term disuse : implications for age-related sarcopenia / Ageing Res Rev 12(4):898~906
Matsumoto Y / 2014 / The non-thermal effects of pulsed ultrasound irradiation on the development of disuse muscle atrophy in rat gastrocnemius muscle / Ultrasound Med Biol 40(7):1578~1586
Powers SK / 2012 / Mitochondrial signaling contributes to disuse muscle atrophy / Am J Physiol Endocrinol Metab 303(1):31~39
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