지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 318 - 324 (7page)
이용수
초록· 키워드
오류제보하기
1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has recently been synthesized and characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide. In the present study, adverse effects of FPP-3 on hepatic functions were determined in female BALB/c mice. When mice were administered with FPP-3 at 125, 250 or 500 mg/kg for 7 consecutive days orally, FPP-3 significantly increased absolute and relative weights of liver with a dose-dependent manner. In addition, FPP-3 administration dramatically increased the hepatotoxicity parameters in serum at 500 mg/kg, in association of hepatic necrosis. FPP-3 significantly induced several phase I enzyme activities. To elucidate the possible mechanism(s) involved in FPP-3 induced hepatotoxicity, we investigated the hepatic activities of free radical generating and scavenging enzymes and the level of hepatic lipid peroxidation. FPP-3 treatment significantly elevated the hepatic lipid peroxidation, measured as the thiobarbituric acid-reactive substance, and the activity of superoxide dismutase. Taken together, the present data indicated that reactive oxygen species might be involved in FPP-3-induced hepatotoxicity.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Immunotoxicological Investigation of 1-furan-2-yl-3-pyridin-2-yl-propenone in Female BALB/c Mice
Biomolecules & Therapeutics(구 응용약물학회지)
2009 .01
-
1-Furan-2-yl-3-pyridin-2-yl-propenone의 TNF-${\apha}$ 유도성 MCP-1과 IL-8의 발현 억제를 통한 장 상피세포 염증 억제효과
약학회지
2008 .01
-
In vitro Characterization of the Enzymes Involved in the Metabolism of 1-furan-2-yl-3-pyridin-2-yl-propenone, an Anti-inflammatory Propenone Compound
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Anti-Tumor and Immunoregulatory Effects of Fermented Papaya Preparation (FPP: SAIDO-PS501)
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Identification of 1-Furan-2-yl-3-pyridin-2-yl-propenone, an Anti-inflammatory Agent, and Its Metabolites in Rat Liver Subcellular Fractions
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
The Effect of 1-Furan-2-yl-3-pyridine-2-yl-propenone on Pharmacokinetic Parameters of Warfarin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Effect of Fertilization Promoting Peptide (FPP) on the Acrosome Status of Cryopreserved Human Sperm
대한불임학회지
2005 .01
-
낙상예방 프로그램이 양로원 여성노인의 보행, 균형 및 근력에 미치는 영향
기초간호자연과학회지
2002 .01
-
Fertilization Promoting Peptide가 사람 정자의 운동양태, 수정능력획득 및 첨체반응에 미치는 영향
대한불임학회지
2000 .01
-
Propenone 유도체의 $NF-{\kappa}B$ 활성 억제 및 IL-8 유도에 의한 단핵구의 장 상피세포 부착 억제 효과
약학회지
2008 .01
-
Effect of Fertilization Promoting Peptide (FPP) Treatment on the Intact Acrosome of Cryopreserved Human Sperm
대한생식의학회 학술대회
2001 .01
-
Inhibition of nitric oxide and TNF-$\alpha$ production by propenone compound through blockaded of NF-$\kappa$B activation in cultured murine macrophages
대한약학회 학술대회
2003 .01
-
Toxicogenomics Analysis on Thioacetamide-induced Hepatotoxicity in Mice
Molecular & cellular toxicology
2006 .01
-
The Effect of Cichorium intybus Extract on Hepatotoxicity in Rats
한국환경보건학회지
2006 .01
-
Anti-obese related pharmacological effects of standard potato protein extracts on the 45%Kcal high fat diet supplied mice
대한예방한의학회지
2018 .01
-
간장독성에서 니트릭 옥시드의 양면적 효과
약학회지
1998 .01
-
영구적인 근력 약화를 보이는 Andersen-Tawil syndrome
대한근전도 전기진단의학회지
2011 .01
-
The Effect of Petasites japonicus Extract on Hepatotoxicity in Rats
한국환경보건학회지
2007 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0