지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 251 - 255 (5page)
이용수
초록· 키워드
오류제보하기
Natural products originating from plants have various beneficial pharmacological effects, such as anticancer, antimicrobial, and anti-inflammatory activities, while being nontoxic. Therefore, tremendous efforts have been invested in understanding their bioactivities in the body to facilitate therapeutic target validation. However, such research is still challenging for certain natural products, such as flavonoids, which are rapidly metabolized in and eliminated from the human body. To investigate the bioactivities of such products, particularly in certain tissues, it is necessary to understand their biodistribution in vivo. In this respect, reliable analytical methods with simple and efficient procedures for the in vivo evaluation of natural small molecules are urgently required. In particular, mass spectrometry (MS) can be effectively used to analyze small molecules after tissue extraction, as MS has various advantages including accuracy, simplicity, and high sensitivity. Herein, we report the biodistribution of a natural small molecule by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). After intravenously injecting gomisin H into a mouse as a model natural product, it was extracted from each organ and then analyzed by MALDI-TOF MS. The analysis showed that gomisin H accumulated mainly in the liver and relatively large amounts of the product existed in the kidney and brain compared to those in other tissues.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The classification and identification of thylakoid membranes of leafy vegetables by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)
한국농약과학회 학술발표대회 논문집
2018 .10
-
The classification and identification of thylakoid membranes of leafy vegetables by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)
한국잡초학회 별책(학술대회 초록집)
2018 .10
-
Analysis of alkanethiolates on gold with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Applied Biological Chemistry
2015 .01
-
Effect of natural product A on Sarcopenia in aging mice
한국식품영양과학회 학술대회발표집
2022 .10
-
Multi-residue method for the determination of 315 pesticides in agricultural products by gas chromatography-mass spectrometry
한국식품영양과학회 학술대회발표집
2016 .10
-
Standardization of natural products targeting joint health improvement
한국식품영양과학회 학술대회발표집
2018 .10
-
Method validation of heavy metals from fishery products using by inductively coupled plasma-mass spectrometry (ICP-MS)
한국식품영양과학회 학술대회발표집
2023 .10
-
Application of a liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-ToF/MS) to discriminate adulterated honey
한국식품영양과학회 학술대회발표집
2022 .10
-
Non-target Analysis for Safety Management of Agricultural, Livestock and Fishery Products
한국농약과학회 학술발표대회 논문집
2022 .11
-
Method validation of polycyclic aromatic hydrocarbons Using by gas chromatography-mass spectrometry from home meal replacement products
한국식품영양과학회 학술대회발표집
2023 .10
-
Discovery of Biomedical Materials from Jeonnam Natural Resources
한국식품영양과학회 학술대회발표집
2021 .10
-
Mass Spectrometry-Based Metabolite Profiling Associated with Plasma Childhood Obesity Genes
한국식품영양과학회 학술대회발표집
2016 .10
-
Metabolite study of Perilla frutescens using Ultraperformance Liquid chromatography coupled with Q-TOF Mass Spectrometry (UPLC/Q-TOF MS)
한국식품영양과학회 학술대회발표집
2019 .10
-
Anti-obesity effects of a standardized water extract from the natural product by regulating the AMPK signaling in HFD-induced mice
한국식품영양과학회 학술대회발표집
2024 .10
-
Flavonoid Characteristics in Flesh and Peel of Mandarin Fruit Using High-Resolution Mass Spectrometry
한국식품영양과학회 학술대회발표집
2024 .10
-
Leveraging big data and AI technology for enhanced discovery of functional natural products
한국식품영양과학회 학술대회발표집
2024 .10
-
Anti-inflammatory activity and structural analysis of fucoidan extracted from Sargassum fusiforme via ESI-TOF MS spectrometry
한국식품영양과학회 학술대회발표집
2024 .10
-
Metabolic Profiling of Red Cabbage Seed Sprouts Ingredients : Multivariate Analysis by HPLC/ESI/q-TOF Mass Spectrometry
한국식품영양과학회 학술대회발표집
2018 .10
-
Structural characterization of flavonoid glycosides in Jeju Putgyul (Unripe citrus) extract using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry
한국식품영양과학회 학술대회발표집
2020 .10
-
The Effects of Marine Algal Natural Product on Inflammatory Myopathy in In vitro and In vivo Zebrafish Model
한국식품영양과학회 학술대회발표집
2018 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0