지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 210 - 215 (6page)
이용수
초록· 키워드
오류제보하기
Colorectal cancer is one of the leading causes of cancer related death due to a poor prognosis. In this study, we investigated the effect of Gomisin G on colon cancer growth and examined the underlying mechanism of action. We found that Gomisin G significantly suppressed the viability and colony formation of LoVo cells. Gomisin G reduced the phosphorylation level of AKT implying that Gomisin G suppressed the PI3K-AKT signaling pathway. Gomisin G also induced apoptosis shown by Annexin V staining and an increased level of cleaved poly-ADP ribose polymerase (PARP) and Caspase-3 proteins. Furthermore, Gomisin G remarkably triggered the accumulation of cells at the sub-G1 phase which represents apoptotic cells. In addition, the level of cyclin D1 and phosphorylated retinoblastoma tumor suppressor protein (Rb) was also reduced by the treatment with Gomisin G thus curtailing cell cycle progression. These findings show the suppressive effect of Gomisin G by inhibiting proliferation and inducing apoptosis in LoVo cells. Taken together, these results suggest Gomisin G could be developed as a potential therapeutic compound against colon cancer.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Alao JP / 2007 / The regulation of cyclin D1 degradation : roles in cancer development and the potential for therapeutic invention / Mol Cancer 6:24
Arnold M / 2017 / Global patterns and trends in colorectal cancer incidence and mortality / Gut 66:683~691
Boatright KM / 2003 / Mechanisms of caspase activation / Curr Opin Cell Biol 15:725~731
Chaitanya GV / 2010 / PARP-1 cleavage fragments : signatures of cell-death proteases in neurodegeneration / Cell Commun Signal 8:31
Chen DF / 1997 / Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues / Bioorg Med Chem 5:1715~1723
Arnold M / 2017 / Global patterns and trends in colorectal cancer incidence and mortality / Gut 66:683~691
Boatright KM / 2003 / Mechanisms of caspase activation / Curr Opin Cell Biol 15:725~731
Chaitanya GV / 2010 / PARP-1 cleavage fragments : signatures of cell-death proteases in neurodegeneration / Cell Commun Signal 8:31
Chen DF / 1997 / Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues / Bioorg Med Chem 5:1715~1723
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Study for the inhibition of transient receptor potential vanilloid type 1 by gomisin A
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Erratum to "Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1" [Biomol.Ther. 26 (2018) 322-327]
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
SD-317 inhibits cell growth and proliferation by preventing activation of Akt in lung cancer
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Kaempferol Synergistically Enhances Cisplatin-induced Apoptosis and Cell Cycle Arrest in Colon Cancer Cells
대한암예방학회지
2024 .09
-
Quantitative Analysis of Schizandrin and Gomisin A in Traditional Herbal Formula, Saengmaek-san
한약정보연구회지
2019 .01
-
Dioscin Decreases Breast Cancer Stem-like Cell Proliferation via Cell Cycle Arrest by Modulating p38 Mitogen-activated Protein Kinase and AKT/mTOR Signaling Pathways
대한암예방학회지
2021 .09
-
Methyl lucidone induces apoptosis and G2/M phase cell cycle arrest in ovarian cancer cells by targeting PI3K/AKT/NF-κB signaling pathway
한국실험동물학회 학술발표대회 논문집
2019 .01
-
유방암 줄기세포 개념 및 제한점
의생명과학
2018 .01
-
Survival analysis for colon subsite and rectal cancers : Experience from a single surgeon
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2015 .12
-
In vitro and In vivo costunolide inhibits the growth of colorectal cancer cells and induces apoptosis
한국실험동물학회 학술발표대회 논문집
2022 .07
-
AKT1-targeted proapoptotic activity of compound K in human breast cancer cells
Journal of Ginseng Research
2019 .10
-
How Can We Treat Cancer Disease Not Cancer Cells?
Cancer Research and Treatment
2017 .01
-
Lentivirus-Mediated Short-Hairpin RNA Targeting Protein Phosphatase 4 Regulatory Subunit 1 Inhibits Growth in Breast Cancer
Journal of Breast Cancer
2015 .01
-
Cigarette smoke components induced apoptosis in SW620 human colon cancer cells via ROS-induced ER-stress pathway
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Costunolide suppresses progression of oral cancer cells via reactive oxygen species and AKT signaling pathway
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo
Cancer Research and Treatment
2017 .07
-
The Nedd8-activating enzyme inhibitor MLN4924 suppresses colon cancer cell growth via triggering autophagy
The Korean Journal of Physiology & Pharmacology
2018 .11
-
Synergistic Anti-Cancer Effects of AKT and SRC Inhibition in Human Pancreatic Cancer Cells
Yonsei Medical Journal
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0