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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제61권 제3호
- 발행연도
- 2018.1
- 수록면
- 275 - 281 (7page)
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초록· 키워드
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Pinus densiflora root (PDR) is used as a medicinal plant. In this study, we investigated whether the PDR extract has anti-inflammatory activities. Cell viability assays showed that the extract was not toxic toward RAW 264.7 cells at concentrations up to $10{\mu}g/mL$. At $10{\mu}g/mL$, the extract decreased nitric oxide (NO) content to 40% of the control level. The protein expression of inducible nitric oxide synthase (iNOS), which generates NO, decreased with increasing concentrations of the extract. Prostaglandin $E_2$ ($PGE_2$) levels were significantly inhibited by over 50% in the presence of $10{\mu}g/mL$ of the extract. The protein expression of cyclooxygenase-2 (COX-2), which generates $PGE_2$, decreased with increasing concentrations of the extract. Proinflammatory cytokines, such as tumor necrosis factor-alpha ($TNF-{\alpha}$), interleukin-6 (IL-6), and $IL-1{\beta}$, were detected in RAW 264.7 cells after lipopolysaccharide (LPS) treatment. The extract did not affect the levels of $TNF-{\alpha}$ and IL-6, but it significantly inhibited the level of $IL-1{\beta}$. It also completely inhibited the transcription of nuclear factor-kappaB ($NF-{\kappa}B$). These results indicate that the PDR extract reduces inflammatory response-related proteins, such as NO, $PGE_2$, iNOS, and COX-2, in LPS-induced RAW 264.7 cells via the regulation of $NF-{\kappa}B$. Consequently, we have provided a mechanism to explain the anti-inflammatory effect of the PDR extract; that is, it exerts such an effect by regulating $NF-{\kappa}B$. The PDR extract can therefore be considered as an effective anti-inflammatory agent.
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참고문헌 (34)
참고문헌 신청
Ran S / 2012 / Macrophage-mediated lymphangiogenesis: The emerging role of macrophages as lymphatic endothelial progenitors / Cancers 4:618~657
Xie QW / 1993 / Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide / J Exp Med 177:1779~1784
Nathan C / 1992 / Nitric oxide as a secretory product of mammalian cells / FASEB J 6:3051~3064
Lawrence T / 2002 / Anti-inflammatory lipid mediators and insights into the resolution of inflammation / Nat Rev Immunol 2:787~795
Nathan CF / 1991 / Role of nitric oxide synthesis in macrophage antimicrobial activity / Current Opinions in Immunology 3:65~70
Xie QW / 1993 / Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide / J Exp Med 177:1779~1784
Nathan C / 1992 / Nitric oxide as a secretory product of mammalian cells / FASEB J 6:3051~3064
Lawrence T / 2002 / Anti-inflammatory lipid mediators and insights into the resolution of inflammation / Nat Rev Immunol 2:787~795
Nathan CF / 1991 / Role of nitric oxide synthesis in macrophage antimicrobial activity / Current Opinions in Immunology 3:65~70
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