Imaging Atherosclerosis in the Carotid Arteries with F-18-Fluoro-2-deoxy-D-glucose Positron Emission Tomography: Effect of Imaging Time after Injection on Quantitative Measurement

Oh, Min-Young; Kim, Ji-Young; Shin, Kwang-Ho; Park, Seol-Hoon; Ryu, Jin-Sook; Kim, Jae-Seung; Kim, Hye-Jin; Kang, Dong-Wha; Moon, Dae-Hyuk

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저자정보: Oh, Min-Young (Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine) Kim, Ji-Young (Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine) Shin, Kwang-Ho (Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine) Park, Seol-Hoon (Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine) Ryu, Jin-Sook (Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine) Kim, Jae-Seung (Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine) Kim, Hye-Jin (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) Kang, Dong-Wha (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) Moon, Dae-Hyuk (Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine)

저널정보: 대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제44권 제4호

발행연도: 2010.1

수록면: 261 - 266 (6page)

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Purpose To compare F-18-fluoro-2-deoxy-D-glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) imaging at two different circulation times after injection of F-18 FDG in order to measure atherosclerosis in carotid arteries. Methods We assessed 12 patients with recent symptomatic plaques in the carotid arteries. F-18 FDG PET/CT carotid plaque imaging was performed for 20 min at 2 h after F-18 FDG injection in five patients and at 3 h in seven patients. We measured vessel wall uptake using the maximal standardized uptake value (SUV), and the mean and maximal blood target-to-background ratios (TBR) of the symptomatic carotid arteries. Blood pool activity (BPA) was measured as the mean SUV of the superior vena cava (SVC) and jugular vein of these 12 patients, and in 14 ageand gender-matched patients who underwent whole-body F-18 FDG PET/CT examinations 1 h after injection. Results F-18 FDG PET/CT revealed visible F-18 FDG uptake in all patients with symptomatic carotid plaques. Maximal SUV did not differ between groups evaluated at 2 h and 3 h ($2.62{\pm}0.45$ vs $3.00{\pm}0.85$, p=0.335). However, mean ($2.04{\pm}0.22$ vs $3.54{\pm}0.62$, p<0.05) and maximal ($1.65{\pm}0.15$ vs $2.70{\pm}0.42$, p<0.05) TBR values that were normalized to BPA in the SVC differ significantly. Conclusions Symptomatic carotid plaques are visualized for a relatively short period of imaging time on ${\geq}1$-h PET/CT images. Quantitative parameters of atherosclerotic carotid arteries are preserved or even increased over time, whereas those of blood pools are decreased.

#F-18 FDG PET/CT #Atherosclerosis #Carotid arteries #Imaging time

참고문헌 (21)

참고문헌 신청

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Izquierdo-Garcia D / 2009 / Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose positron emission tomography in human carotid arteries: reproducibility, partial volume correction, and correlation between methods / Stroke 40:86~93

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Chen W / 2009 / Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries / Eur J Nucl Med Mol Imaging 36:144~151

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