Clinical Characteristics Associated with Long-term Survival in Metastatic Gastric Cancer after Systemic Chemotherapy

Kadowaki, Shigenori; Komori, Azusa; Takahari, Daisuke; Ura, Takashi; Ito, Seiji; Tajika, Masahiro; Niwa, Yasumasa; Oze, Isao; Muro, Kei

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자료유형: 학술저널

저자정보: Kadowaki, Shigenori (Department of Clinical Oncology, Aichi Cancer Center Hospital) Komori, Azusa (Department of Clinical Oncology, Aichi Cancer Center Hospital) Takahari, Daisuke (Department of Clinical Oncology, Aichi Cancer Center Hospital) Ura, Takashi (Department of Clinical Oncology, Aichi Cancer Center Hospital) Ito, Seiji (Department of Gastroenterological Surgery, Aichi Cancer Center Hospital) Tajika, Masahiro (Department of Endoscopy, Aichi Cancer Center Hospital) Niwa, Yasumasa (Department of Endoscopy, Aichi Cancer Center Hospital) Oze, Isao (Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute) Muro, Kei (Department of Clinical Oncology, Aichi Cancer Center Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제13호

발행연도: 2015.1

수록면: 5,433 - 5,438 (6page)

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Background: Systemic chemotherapy for patients with metastatic gastric cancer (MGC) is generally palliative, although some patients experience long-term survival after treatment. Thus, we identified clinical characteristics that are associated with long-term survival of patients with MGC after palliative chemotherapy. Materials and Methods: We retrospectively reviewed 514 MGC patients who received systemic chemotherapy at our institution from 2001 to 2008. To identify clinical predictors of survival beyond 2 years, multivariate logistic regression analyses were performed, and 5-year survival rates were estimated among MGC patients following chemotherapy. Results: Among 514 patients, 96 (19%) and 16 (3%) survived beyond 2 and 5 years, respectively, and performance status of 0 or 1 (odds ratio [OR]=3.39; p=0.01), previous gastrectomy (OR=1.86; p=0.01), single metastatic site (OR=1.80; p=0.03), and normal alkaline phosphatase levels (OR=2.81; p<0.01) were identified as independent predictors of long-term survival. Of the 16 5-year survivors, six were alive at the end of the study and showed no evidence of disease despite cessation of chemotherapy. Conclusions: The present data demonstrate distinct clinical characteristics that are associated with long-term survival of MGC patients, and indicated that palliative chemotherapy can be curative in highly selected patients.

#Advanced gastric cancer #chemotherapy #predictive factor #survival

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