지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 48 - 57 (10page)
- DOI
- https://doi.org/10.5230/jgc.2018.18.e4
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초록· 키워드
오류제보하기
Purpose: Postoperative adjuvant chemotherapy is usually prescribed to improve the survival of patients with advanced gastric cancer who undergo curative surgery. This study was designed to determine the impact that the degree of compliance with chemotherapy has on the prognosis of patients with gastric cancer.
Materials and Methods: Among 252 patients with stage III gastric cancer who underwent curative surgery between July 2004 and December 2014, 85 patients were postoperatively treated with S-1, the oral fluoropyrimidine derivative, 23 received no chemotherapy, and 144 received other regimens. Overall survival was compared between the complete compliance group (who received 8 cycles of S-1 chemotherapy, n=44) and the incomplete compliance group (who received less than 8 cycles of S-1 chemotherapy, n=41). Factors that influenced patient compliance with chemotherapy were also analyzed.
Results: The overall 5-year survival rate was significantly different between the complete chemotherapy and incomplete chemotherapy groups (80.0% vs. 42.7%, P<0.001). Based on univariate and multivariate survival analyses of patients who received S-1 chemotherapy, the independent prognostic factors were tumor, node, and metastasis (TNM) stage (IIIa vs. IIIb vs. IIIc) and compliance with chemotherapy. TNM stage and age are significant factors that influence compliance with chemotherapy.
Conclusions: TNM stage and compliance with chemotherapy are independent prognostic factors in patients with stage III gastric cancer who received postoperative chemotherapy. TNM stage and age are significant factors that influence patient compliance with chemotherapy.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Rugge M / 2015 / Gastric Cancer: Principles and Practice / Springer :23~34
Orditura M / 2014 / Treatment of gastric cancer / World J Gastroenterol 20:1635~1649
Wagner AD / 2010 / Chemotherapy for advanced gastric cancer / Cochrane Database Syst Rev
Kilic L / 2016 / Current adjuvant treatment modalities for gastric cancer: from history to the future / World J Gastrointest Oncol 8:439~449
Fuentes E / 2016 / Adjuvant therapy completion rates in patients with gastric cancer undergoing perioperative chemotherapy versus a surgery-first approach / J Gastrointest Surg 20:172~179
Orditura M / 2014 / Treatment of gastric cancer / World J Gastroenterol 20:1635~1649
Wagner AD / 2010 / Chemotherapy for advanced gastric cancer / Cochrane Database Syst Rev
Kilic L / 2016 / Current adjuvant treatment modalities for gastric cancer: from history to the future / World J Gastrointest Oncol 8:439~449
Fuentes E / 2016 / Adjuvant therapy completion rates in patients with gastric cancer undergoing perioperative chemotherapy versus a surgery-first approach / J Gastrointest Surg 20:172~179
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