Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population

Anil, Sukumaran; Gopikrishnan, PB; Basheer, Ashik Bin; Vidyullatha, BG; Alogaibi, Yahya A; Chalisserry, Elna P; Javed, Fawad; Dalati, MHN; Vellappally, Sajith; Hashem, Mohamed Ibrahim; Divakar, Darshan Devang

추천

검색

자료유형: 학술저널

저자정보: Anil, Sukumaran (Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University) Gopikrishnan, PB (Department of Conservative Dentistry and Endodontist, PSM College of Dental Sciences and Research) Basheer, Ashik Bin (Department of Oral and Maxillofacial Pathology, PSM College of Dental Sciences and Research) Vidyullatha, BG (Department of Oral and Maxillofacial Surgery and Diagnostic sciences, King Saud Bin Abdulaziz University for Health Sciences) Alogaibi, Yahya A (Department of Orthodontics, Faculty of Dentistry, King Abdulaziz University) Chalisserry, Elna P (Department of Maxillofacial Surgery & Diagnostic Sciences, College of Dentistry, College of Dentistry, Jazan University) Javed, Fawad (Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester) Dalati, MHN (Consultant Orthodontist and Restorative Dentist, Springs Dental Care) Vellappally, Sajith (Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University) Hashem, Mohamed Ibrahim (Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medica) Divakar, Darshan Devang

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제8호

발행연도: 2016.1

수록면: 4,107 - 4,111 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Oral cancers account for approximately 2% of all cancers diagnosed each year; however, the vast majority (80%) of the affected individuals are smokers whose risk of developing a lesion is five to nine times greater than that of non-smokers. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which poly (ADP-ribose) polymerase 1 (PARP-1), plays key roles. Genetic variations in the genes encoding DNA repair enzymes may alter their functions. Several studies reported mixed effects on the association between PARP-1 variants and the risk of cancer development. Till now no reported studies have investigated the association between PARP-1 variants and oral squamous cell carcinoma (OSCC) risk in an Indian population. Materials and Methods: In the present case control study 100 OSCC patients and 100 matched controls were genotyped using PARP1 single nucleotide peptides (SNP's) rs1136410 and rs3219090 using TaqMan assays. Results: The results indicated significantly higher risk with PARP1 rs1136410 minor allele "C" (OR=1.909; p=0.02942; CI, 1.060-3.439). SNP rs1136410 also showed significantly increased risk in patients with smoking habit at C/C genotype and at minor allele C. Conclusions: The PAPR-1 Ala762Val polymorphism may play a role in progression of OSCC. Larger studies with a greater number of samples are needed to verify these findings.

#Oral squamous cell carcinoma #poly #ADP-Ribose) polymerase 1 #risk factor

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

Anil, Sukumaran

소속기관 Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz Universi