지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제4호
- 발행연도
- 2016.1
- 수록면
- 2,151 - 2,157 (7page)
이용수
초록· 키워드
오류제보하기
Scabraside D, a sulfated triterpene glycoside, was extracted from the sea cucumber Holothuria scabra. It shows anti-proliferation in many of cancer cell lines, but the function and mechanisms of action of scabraside D in human cholangiocarcinoma (HuCCA) have not previously determined. In this study, we investigated the activity of scabraside D on HuCCA cell apoptosis, lymphangiogenesis and metastasis in a nude mouse model. Scabraside D induced signs of apoptosis, such as cell shrinkage, nuclear condensation, nuclear fragmentation and DNA fragmentation on TUNEL assays, while effectively decreasing expression of BCl-2 but increasing caspase-3 gene level expression. Immunohistochemistry revealed that scabraside D significantly reduced lymphatic vessel density (LVD). Moreover, scabraside D treatment significantly decreased VEGF-C, MMP-9 and uPA gene expression, which play important roles in the lymphangiogenesis and invasion of cancer cells in metastasis processes. Quantitative real-time PCR showed that scabraside D significantly decreased iNOS and STAT-3 gene expression. This study demonstrated that scabraside D plays a role in activation of HuCCA tumor apoptosis and inhibition of lymphangiogenesis, invasion and metastasis through decreasing BCl-2, MMP-9, uPA and VEGF-C and increasing caspase-3 expression by suppression of iNOS and STAT-3 expression. Therefore, scabraside D could be a promising candidate for cholangiocarcinoma treatment.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Scabraside D Extracted from Holothuria scabra Induces Apoptosis and Inhibits Growth of Human Cholangiocarcinoma Xenografts in Mice
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Quercetin Down-regulates IL-6/STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Non-small-cell Lung-cancer Cell Line, A549
Journal of Pharmacopuncture
2015 .01
-
Mandibular metastasis of cholangiocarcinoma: A case report
Imaging science in dentistry
2015 .01
-
Nitidine chloride acts as an apoptosis inducer in human oral cancer cells and a nude mouse xenograft model via inhibition of STAT3
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Anticancer effects of 3-Formylchromone in multiple myeloma
대한동의병리학회 학술대회논문집
2015 .10
-
Potential application of Natural agents derived from traditional Chinese Medicine for cancer therapy
대한동의병리학회 학술대회논문집
2015 .10
-
Orostachys japonicus DW and EtOH Extracts Induce Apoptosis in Cholangiocarcinoma Cell Line SNU-1079
대한한의학회지
2015 .12
-
Inhibitory Effects of Schisandra chinensis Seed Extracts on Breast Cancer
대한의생명과학회지
2025 .03
-
Micro RNA 34a and Let-7a Expression in Human Breast Cancers is Associated with Apoptotic Expression Genes
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Genetic features associated with 18F-FDG uptake in intrahepatic cholangiocarcinoma
Annals of Surgical Treatment and Research
2019 .04
-
담관암에서 성장인자-매개 암 진행과 전이
대한췌담도학회지
2015 .01
-
Comparison of clinical results of surgical resection for extrahepatic cholangiocarcinomas : hilar cholangiocarcinoma and mid to distal cholangiocarcinoma.
대한외과학회 학술대회 초록집
2017 .11
-
간내 담관암: 최신 개념 및 내과적 치료
대한췌담도학회지
2021 .01
-
T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response
Immune Network
2018 .08
-
Anti-tumor Activity of Schoenoplectus triqueter Extract by Suppressing the STAT3 Signaling Pathway in A549 Lung Adenocarcinoma Cells
Natural Product Sciences
2024 .09
-
Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Clinicopathological Significance of Osteopontin in Cholangiocarcinoma Cases
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Effect of STAT3 on Lysophosphatidic Acid-Induced Oral Cancer Cell Invasion
치위생과학회지
2019 .01
-
STAT3 as a Potential Target for Tumor Suppressive Effects of 15-Deoxy-Δ12,14-prostaglandin J2 in Triple Negative Breast Cancer
대한암예방학회지
2021 .09
-
Quantitative Changes in Tumor-Associated M2 Macrophages Characterize Cholangiocarcinoma and their Association with Metastasis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0