Frequency of EGFR Mutations in Non-small Cell Lung Cancer Patients: Screening Data from West Siberia

Gervas, Polina; Ivanova, Anna; Vasiliev, Nikolay; Ananina, Olga; Zharkova, Olga; Rogovieva, Olga; Verzhbitskaya, Natalia; Didichuk, Ivan; Cheremisina, Olga; Popova, Natalia; Goldberg, Victor; Cherdyntsev, Evgeny; Choynzonov, Evgeny; Cherdyntseva, Nadezda

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자료유형: 학술저널

저자정보: Gervas, Polina (Federal State Budgetary Scientific Institution "Tomsk Cancer Research Institute") Ivanova, Anna (Federal State Budgetary Scientific Institution "Tomsk Cancer Research Institute") Vasiliev, Nikolay (Federal State Budgetary Scientific Institution "Tomsk Cancer Research Institute") Ananina, Olga (Federal State Budgetary Scientific Institution "Tomsk Cancer Research Institute") Zharkova, Olga (Regional Clinical Oncology Center) Rogovieva, Olga (Regional Clinical Oncology Center) Verzhbitskaya, Natalia (Regional Clinical Oncology Center) Didichuk, Ivan (Clinical Oncology Center) Cheremisina, Olga (Federal State Budgetary Scientific Institution "Tomsk Cancer Research Institute") Popova, Natalia (Federal State Budgetary Scientific Institution "Tomsk Cancer Research Institute") Goldberg, Victor (Federal State Budgetary Scientific Institution "Tomsk Cancer Research Institute") Cherdyntsev, Evgeny (National Research Tomsk Polytechnic University) Choynzonov, Evgeny (Federal State Budgetary Scientific Institution "Tomsk Cancer Research Institute") Cherdyntseva, Nadezda (Federal State Budgetary Scientific Institution "Tomsk Cancer Research Institute")

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제2호

발행연도: 2015.1

수록면: 689 - 692 (4page)

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Background: Incorporation of molecular analysis of the epidermal growth factor receptor (EGFR) gene into routine clinical practice has shown great promise to provide personalized therapy of the non-small cell lung cancer (NSCLC) in the developed world. However, the genetic testing of EGFR mutations has not yet become routine clinical practice in territories remote from the central regions of Russia. Therefore, we aimed to study the frequency of major types of activating mutations of the EGFR gene in NSCLC patients residing in West Siberia. Materials and Methods: We examined EGFR mutations in exons 19 and 21 in 147 NSCLC patients (excluding squamous cell lung carcinomas) by real time polymerase chain reaction. Results: EGFR mutations were detected in 28 of the 147 (19%) patients. There were 19 (13%) cases with mutations in exon 19 and 9 cases (6%) in exon 21. Mutations were more frequently observed in women (42%, p=0.000) than in men (1%). A significantly higher incidence of EGFR mutations was observed in bronchioloalveolar carcinomas (28%, p=0.019) and in adenocarcinomas (21%, p=0.024) than in large cell carcinomas, mixed adenocarcinomas, and NOS (4%). The EGFR mutation rate was much higher in never-smokers than in smokers: 38% vs. 3% (p=0.000). The frequency of EGFR mutations in the Kemerovo and Tomsk regions was 19%. Conclusions: The incorporation of molecular analysis of the EGFR gene into routine clinical practice will allow clinicians to provide personalised therapy, resulting in a significant increase in survival rates and improvement in life quality of advanced NSCLC patients.

#Non-small cell lung cancer #epidermal growth factor receptor #Western Siberia

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