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논문 기본 정보

자료유형
학술저널
저자정보
정용준 (서울대학교 자연과학대학 생명과학부) 한동오 (경희대학교 침구경락과학연구센터) 최보희 ([주]파스카바이오,[주]디와이) 박철 (경희대학교 침구경락과학연구센터) 이혜정 (경희대학교 침구경락과학연구센터, 경희대학교 한의과대학 경혈학교실) 김성훈 (경희대학교 한의과대학 병리학교실) 함대현 (경희대학교 침구경락과학연구센터, 경희대학교 한의학연구소)
저널정보
대한동의생리학회 동의생리병리학회지 동의생리병리학회지 제21권 제2호
발행연도
2007.1
수록면
387 - 391 (5page)

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Recently, much attention has been paid to developing various kinds of fermented herbal extracts, a new type of traditional herbal medicine, in the field of Korean traditional medicine. The fermentation of medicinal herbs is intended to exert a favorable influence on digestability, bioavailavility and pharmacological activity of herbal extract in the gastrointestinal tract. It also produces a number of fermentation products that intensify the nutritional and pharmacological aspects of the medicinal herbs. In order to develop a functional beverage of alleviating the aftereffects of the previous drinks, the extracts (HP-1) of fermented herbal mixture, including Artemisia capillaris Thunb., Lonicera japonica Thunberg, and Hovenia dulcis Thunb., were prepared and the medicinal effect as a hangover cure was evaluated in ethanol-loaded rats. The enzyme activities of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase-2 (ALDH2) were analyzed by measuring the concentration of blood ethanol and acetaldehyde. The mRNA expression of ADH and ALDH2 was also investigated through RT-PCR analysis. In the HP-1-treated group, the concentration of blood ethanol was significantly reduced at one hour after loading of ethanol, as compared to that in the saline-treated group. The reduced ethanol was converted to acetaldehyde, which resulted in rapid increase in acetaldehyde concentration in an hour. Acetaldehyde was started to decrease at 5 hours after ethanol loading. It implies that HP-1 is highly effective to stimulate the activities of ADH and ALDH2. The HP-1 treatment also activated the mRNA expression of ADH and ALDH. This study suggests that fermented herbal extract, HP-1 can be used as a functional beverage of alleviating the alcohol-induced hangover symptoms by stimulating the activities and gene expression of hepatic alcohol metabolizing enzymes.

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