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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제4호
- 발행연도
- 2007.1
- 수록면
- 486 - 492 (7page)
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초록· 키워드
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We have previously shown that phosphodiesterase (PDE) inhibitors induce osteoclast formation by suppressing the degradation of intracellular cAMP. To determine the regulatory roles of PDE inhibitors on PGE$_2$-induced osteoclastogenesis, we investigated the effect of PDE inhibitors on osteoclast formation in the presence of PGE$_2$. We found that IBMX, a nonselective PDE inhibitor, and rolipram, a specific PDE4 inhibitor, decreased PGE$_2$-induced osteoclast formation in cocultures of mouse bone marrow cells and osteoblastic cells. These suppressive effects were observed only when cocultures were treated with PDE inhibitors in the presence of PGE$_2$ at an early stage of differentiation. Northern blot analysis revealed that the PDE4 inhibitor works synergistically with PGE$_2$ to increase the ratio of TRANCE/OPG mRNA in osteoblasts suggesting that suppression of osteoclast formation by PGE$_2$ and the PDE4 inhibitor is not attributable to their indirect effect on calvarial osteoblasts. We further demonstrated that the PDE4 inhibitor augments the inhibitory effect of PGE$_2$on osteoclast progenitor cell viability, showing that combined treatment with PGE$_2$ and rolipram suppresses osteoclast formation by directly reducing osteoclast progenitor cell viability.
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