지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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We explored the role of phosphodiesterase 4 (PDE4) on parathyroid (PTH)-induced signaling in osteoblasts. PTH was shown to increase the activity of PDE, mainly PDE4, in osteoblasts, which is partly attributable to elevated PDE4B and PDE4D mRNA expression. The use of PDE4 inhibitor strengthened the PTH-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation. Furthermore, the PDE4 inhibitor stimulated PTH-induced receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL) expression in osteoblasts, which in turn increased osteoclast formation. Taken together, these data suggest the negative role of PDE4 on PTH-induced signaling in osteoblasts.
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참고문헌 (13)
참고문헌 신청
Takahashi, N / 1988 / Osteoblastic cells are involved in osteoclast formation / Endocrinology 123:2600
Suda, T / 1999 / Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families / Endocr. Rev 20:345
Wong, B. R / 1997 / TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun Nterminal kinase in T cells / J. Biol. Chem 272:25190
Yasuda, H / 1998 / Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesisinhibitory factor and is identical to TRANCE/RANKL / Proc.Natl. Acad. Sci. USA 95:3597
Lacey, D. L / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93:165
Suda, T / 1999 / Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families / Endocr. Rev 20:345
Wong, B. R / 1997 / TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun Nterminal kinase in T cells / J. Biol. Chem 272:25190
Yasuda, H / 1998 / Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesisinhibitory factor and is identical to TRANCE/RANKL / Proc.Natl. Acad. Sci. USA 95:3597
Lacey, D. L / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93:165
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