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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 149 - 154 (6page)
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Phosphodiesterase (PDE) 4 inhibitors have been shown to induce the cAMP-mediated signaling pathway by inhibiting cAMP hydrolysis. This study investigated the effect of a PDE4 inhibitor on the expression of the inducible cAMP early repressor (ICER), which is an endogenous inhibitor of CRE- mediated transcription, in osteoblastic cells. RT-PCR analysis revealed that rolipram, a PDE4 inhibitor, stimulates the ICER mRNA in a dose dependent manner. The induction of ICER mRNA expression by rolipram was suppressed by the inhibitors of protein kinase A (PKA) and p38 MAPK, suggesting the involvement of PKA and p38 MAPK activation in ICER expression by rolipram. It was previously shown that rolipram induced the expression of TNF-related activation-induced cytokine (TRANCE, also known as RANKL, ODF, or OPGL) in osteoblasts. This paper provides evidences that a transcriptional repressor like ICER might modulate TRANCE mRNA expression by rolipram in osteoblasts.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
/ / Inducibility and negative autoregulation of CREM an alternative promoter directs the expression of ICER : 875 ~ 86
/ / Regulation of cytokine expression in osteoblasts by parathyroid hormone rapid stimulation of interleukin-6 and leukemia inhibitory factor mRNA : 1163 ~ 71
/ 1995 / PGE2 induces the transition from non-adherent to adherent bone marrow mesenchymal precursor cells via a cAMP/EP2-mediated mechanism 49 : 383 ~ 95
/ 1995 / Thyroid-stimulating hormone (TSH)-directed induction of the CREM gene in the thyroid gland participates in the long-term desensitization of the TSH receptor 92 : 96
/ 1997 / Cross-talk in signal transduction R
/ / Regulation of cytokine expression in osteoblasts by parathyroid hormone rapid stimulation of interleukin-6 and leukemia inhibitory factor mRNA : 1163 ~ 71
/ 1995 / PGE2 induces the transition from non-adherent to adherent bone marrow mesenchymal precursor cells via a cAMP/EP2-mediated mechanism 49 : 383 ~ 95
/ 1995 / Thyroid-stimulating hormone (TSH)-directed induction of the CREM gene in the thyroid gland participates in the long-term desensitization of the TSH receptor 92 : 96
/ 1997 / Cross-talk in signal transduction R
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Anti-inflammatory effects of PDE4 inhibitor in respiratory bacterial infection
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