지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.10
- 수록면
- 425 - 437 (13page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Different fatty acids exert different health benefits. This study investigated the potential protective effects of perilla, olive, and safflower oils on high-fat diet-induced obesity and colon inflammation.
MATERIALS/METHODS: Five-week old, C57BL/6J mice were assigned to 5 groups: low-fat diet (LFD), high-fat diet (HFD) and high-fat diet supplemented with-perilla oil (HPO), olive oil (HOO), and safflower oil (HSO). After 16 weeks of the experimental period, the mice were sacrificed, and blood and tissues were collected. The serum was analyzed for obesity- and inflammation-related biomarkers. Gene expression of the biomarkers in the liver, adipose tissue, and colon tissue was analyzed. Micro-computed tomography (CT) analysis was performed one week before sacrifice.
RESULTS: Treatment with all the three oils significantly improved obesity-induced increases in body weight, liver weight, and epididymal fat weight as well as serum triglyceride and leptin levels. Treatment with perilla oil (PO) and safflower oil (SO) increased adiponectin levels. The micro-CT analysis revealed that PO and SO reduced abdominal fat volume considerably. The mRNA expression of lipogenic genes was reduced in all the three oilsupplemented groups and PO upregulated lipid oxidation in the liver. Supplementation of oils improved macroscopic score, increased colon length, and decreased serum endotoxin and proinflammatory cytokine levels in the colon. The abundance of Bifidobacteria was increased and that of Enterobacteriaceae was reduced in the PO-supplemented group. All three oils reduced proinflammatory cytokine levels, as indicated by the mRNA expression. In addition, PO increased the expression of tight junction proteins.
CONCLUSIONS: Taken together, our data indicate that the three oils exert similar anti-obesity effects. Interestingly, compared with olive oil and SO, PO provides better protection against high-fat diet-induced colon inflammation, suggesting that PO consumption helps manage inflammation-related diseases and provides omega-3 fatty acids needed by the body.
MATERIALS/METHODS: Five-week old, C57BL/6J mice were assigned to 5 groups: low-fat diet (LFD), high-fat diet (HFD) and high-fat diet supplemented with-perilla oil (HPO), olive oil (HOO), and safflower oil (HSO). After 16 weeks of the experimental period, the mice were sacrificed, and blood and tissues were collected. The serum was analyzed for obesity- and inflammation-related biomarkers. Gene expression of the biomarkers in the liver, adipose tissue, and colon tissue was analyzed. Micro-computed tomography (CT) analysis was performed one week before sacrifice.
RESULTS: Treatment with all the three oils significantly improved obesity-induced increases in body weight, liver weight, and epididymal fat weight as well as serum triglyceride and leptin levels. Treatment with perilla oil (PO) and safflower oil (SO) increased adiponectin levels. The micro-CT analysis revealed that PO and SO reduced abdominal fat volume considerably. The mRNA expression of lipogenic genes was reduced in all the three oilsupplemented groups and PO upregulated lipid oxidation in the liver. Supplementation of oils improved macroscopic score, increased colon length, and decreased serum endotoxin and proinflammatory cytokine levels in the colon. The abundance of Bifidobacteria was increased and that of Enterobacteriaceae was reduced in the PO-supplemented group. All three oils reduced proinflammatory cytokine levels, as indicated by the mRNA expression. In addition, PO increased the expression of tight junction proteins.
CONCLUSIONS: Taken together, our data indicate that the three oils exert similar anti-obesity effects. Interestingly, compared with olive oil and SO, PO provides better protection against high-fat diet-induced colon inflammation, suggesting that PO consumption helps manage inflammation-related diseases and provides omega-3 fatty acids needed by the body.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of vegetable oils with different fatty acid composition on high-fat diet-induced obesity and colon inflammation
Nutrition Research and Practice
2020 .10
-
High maysin corn silk extract reduces body weight and fat deposition in C57BL/6J mice fed high-fat diets
Nutrition Research and Practice
2016 .12
-
High maysin corn silk extract reduces body weight and fat deposition in C57BL/6J mice fed high-fat diets
Nutrition Research and Practice
2016 .12
-
Partial replacement of dietary fat with Perilla oil attenuates inflammatory responses and cardiovascular risks in LPS-injected ob/ob mice
한국지역사회생활과학회 학술대회 자료집
2021 .06
-
Inflammation in Obesity
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .12
-
Protective effect of dietary oils containing omega-3 fatty acids against glucocorticoid-induced osteoporosis
Journal of Nutrition and Health
2019 .08
-
Mentha canadensis attenuates adiposity and hepatic steatosis in high-fat diet-induced obese mice
Nutrition Research and Practice
2023 .10
-
Mentha canadensis attenuates adiposity and hepatic steatosis in high-fat diet-induced obese mice
Nutrition Research and Practice
2023 .10
-
Oil spill environmental forensics of crude oils and marine fuel oils
한국분석과학회 학술대회
2019 .05
-
Differential Effects of Western and High-fat Diets on the Acceleration of Psoriatic Inflammation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2024 .12
-
올리브유 대체 비율이 저지방 돈육 패티의 품질 특성에 미치는 영향
생명과학회지
2020 .07
-
The antioxidant activity of steamed ginger and its protective effects on obesity induced by high-fat diet in C57BL/6J mice
Nutrition Research and Practice
2019 .06
-
The antioxidant activity of steamed ginger and its protective effects on obesity induced by high-fat diet in C57BL/6J mice
Nutrition Research and Practice
2019 .06
-
Green perilla leaf extract ameliorates long-term oxidative stress induced by a high-fat diet in aging mice
Nutrition Research and Practice
2022 .10
-
Green perilla leaf extract ameliorates long-term oxidative stress induced by a high-fat diet in aging mice
Nutrition Research and Practice
2022 .10
-
고지방식이로 비만을 유도한 생쥐에서 혈장 케모카인 발현 변화
Journal of Nutrition and Health
2018 .10
-
간호 대학생들의 학습성과 교육요구도 조사
경북간호과학지
2017 .02
-
The Chemical characterization and weathering effect of different crude oils and product oils
한국분석과학회 학술대회
2019 .11
-
Effect of cinacalcet-mediated parathyroid hormone reduction on vitamin D metabolism in high-fat diet-induced obese mice
Journal of Nutrition and Health
2023 .02
-
Determination of Benzo(a)pyrene and Copper chlorophyll in olive oils and grape seed oils
한국분석과학회 학술대회
2023 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2020-594-001155790