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논문 기본 정보

자료유형
학술저널
저자정보
Amr Samir Elbahnasawy (Kazan Federal University) Emiliya Ramzievna Valeeva (Kazan Federal University) Eman Mustafa El-Sayed (National Research Centre) Natalya Vladimirovna Stepanova (Kazan Federal University)
저널정보
한국영양학회 Journal of Nutrition and Health Journal of Nutrition and Health Vol.52 No.4
발행연도
2019.8
수록면
323 - 331 (9page)

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Purpose: Glucocorticoids (GCs) are implicated in secondary osteoporosis, and the resulting fractures cause significant morbidity. Polyunsaturated fatty acids (PUFAs) play a vital role in bone metabolism. However, few trials have studied the impact of omega-3 PUFA-containing oils against GC-induced osteoporosis. Therefore, the present study was undertaken to determine whether supplementation with omega-3 PUFA-containing dietary oils such as fish oil, flaxseed oil or soybean oil can impede the development of GC-induced osteoporosis. Methods: The fatty acids (FAs) content of oils was determined using gas chromatography. Male rats were subdivided into 5 groups (8 rats each): normal control (balanced diet), prednisolone control (10 mg/kg prednisolone daily), soybean oil (prednisolone 10 mg/kg + soybean oil 7% w/w), flaxseed oil (prednisolone 10 mg/kg + flaxseed oil 7% w/w), and fish oil (from cod liver; prednisolone 10 mg/kg + fish oil 7% w/w). Results: The study data exhibited a significant depletion in bone mineral density (BMD) and femur mass in the prednisolone control compared to the normal control, accompanied with a marked decrease in the levels of plasma calcium and 1,25-(OH)₂-vitamin D₃, and elevated levels of C-terminal telopeptide (CTX), tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA). Supplementation with fish oil, soybean oil or flaxseed oil helped to improve plasma calcium levels, and suppress oxidative stress and inflammatory markers. Additionally, bone resorption was suppressed as reflected by the decreased CTX levels. However, fish oil was more effective than the other two oils with a significant improvement in BMD and normal histological results compared to the normal control. Conclusion: This study demonstrated that supplementation with dietary oils containing omega-3 PUFAs such as fish oil, soybean oil or flaxseed oil can play a role in the prevention of bone loss and in the regulation of bone metabolism, especially fish oil which demonstrated a greater level of protection against GC-induced osteoporosis.
#glucocorticoid-induced osteoporosis #fish oil #soybean oil #flaxseed oil #inflammation

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ABSTRACT
Introduction
Methods
Results
Discussion
Summary
References

참고문헌 (48)

참고문헌 신청
Jeremiah MP / 2015 / Diagnosis and management of osteoporosis / Am Fam Physician 92(4):261~268 google schola Akarirmak U / 2018 / Osteoporosis : a major problem-worldwide / Arch Sports Med 2(1):106~108 google schola Wade SW / 2014 / Estimating prevalence of osteoporosis : examples from industrialized countries / Arch Osteoporos 9(1):182 google schola Silverman S / 2015 / International management of bone health in glucocorticoidexposed individuals in the observational GLOW study / Osteoporos Int 26(1):419~420 google schola Wang T / 2019 / Pro-inflammatory cytokines : cellular and molecular drug targets for glucocorticoid-induced-osteoporosis via osteocyte / Curr Drug Targets 20(1):1~15 google schola

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