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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 91 - 91 (1page)
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Various tiered approaches using several alternative test methods for the evaluation of eye irritation are being developed. This study aimed to develop tiered approaches to predict eye irritation. Three OECD adopted alternative test methods encompassing different test systems for eye irritation, Short Time Exposure (STE), Bovine Corneal Opacity and Permeability (BCOP), and Reconstructed human Cornea-like Epithelium test (RhCE)(EpiocularTM), were selected. Additionally, two alternative test methods widely used in the safety assessment and research in Korea, Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) and RhCE test (MCTT HCETM), were selected. Also, 75 test chemicals clearly classified as UN GHS Category 1, 2, or No Category were selected from the Draize eye test Reference Database to compare the prediction results of the proposed tiered approaches with UN GHS Category. The test method for the first stage of a tiered approach was selected by ... 전체 초록 보기
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