지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.100 No.4
- 발행연도
- 2021.4
- 수록면
- 209 - 217 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: This study aimed to compare treatment options and outcomes based on peritoneal cancer index (PCI) among patients with peritoneal metastasis (PM) of advanced gastric cancer (AGC).
Methods: Between January 2016 and July 2019, clinicopathological data of patients with AGC diagnosed with PM were reviewed. Different treatment methods were performed according to the PCI score: (1) group A (PCI ≤ 13) received cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with postoperative intraperitoneal (IP) and systemic chemotherapy (n = 29), while (2) group B (PCI > 13) received IP chemotherapy with systemic chemotherapy (n = 22).
Results: Clinical outcomes of 51 patients at the Dankook University Hospital were reviewed. Group A had a significantly lower mean PCI score (9.8 ± 6.9 vs. 32.6 ± 7.1, P < 0.01) than group B, with 25 patients (86.2%) achieving complete cytoreduction. Complications occurred in 16 patients (31.4%), none of who suffered mortality (group A: 11 patients, 37.9% vs. group B: 5 patients, 22.7%; P = 0.25). Among the morbidity, 5 cases (17.2%) and 2 cases (9.1%) exhibited a Clavien-Dindo grade greater than III in groups A and B, respectively (P = 0.04). Groups A and B had an overall median survival time of 34.0 and 16.0 months, respectively (P = 0.03).
Conclusion: Patients with PM of AGC received different treatments according to their PCI score. When accompanied with careful patient selection, our approach may be considered an acceptable option for the treatment of PM of AGC.
Methods: Between January 2016 and July 2019, clinicopathological data of patients with AGC diagnosed with PM were reviewed. Different treatment methods were performed according to the PCI score: (1) group A (PCI ≤ 13) received cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with postoperative intraperitoneal (IP) and systemic chemotherapy (n = 29), while (2) group B (PCI > 13) received IP chemotherapy with systemic chemotherapy (n = 22).
Results: Clinical outcomes of 51 patients at the Dankook University Hospital were reviewed. Group A had a significantly lower mean PCI score (9.8 ± 6.9 vs. 32.6 ± 7.1, P < 0.01) than group B, with 25 patients (86.2%) achieving complete cytoreduction. Complications occurred in 16 patients (31.4%), none of who suffered mortality (group A: 11 patients, 37.9% vs. group B: 5 patients, 22.7%; P = 0.25). Among the morbidity, 5 cases (17.2%) and 2 cases (9.1%) exhibited a Clavien-Dindo grade greater than III in groups A and B, respectively (P = 0.04). Groups A and B had an overall median survival time of 34.0 and 16.0 months, respectively (P = 0.03).
Conclusion: Patients with PM of AGC received different treatments according to their PCI score. When accompanied with careful patient selection, our approach may be considered an acceptable option for the treatment of PM of AGC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Kim HH / 2019 / Effect of laparoscopic distal gastrectomy vs open distal gastrectomy on long-term survival among patients with stage I gastric cancer: the KLASS-01 randomized clinical trial / JAMA Oncol 5:506~513
Sakuramoto S / 2007 / Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine / N Engl J Med 357:1810~1820
Noh SH / 2014 / Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC):5-year follow-up of an open-label, randomised phase 3 trial / Lancet Oncol 15:1389~1396
Koizumi W / 2008 / S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial / Lancet Oncol 9:215~221
Kang YK / 2009 / Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial / Ann Oncol 20:666~673
Sakuramoto S / 2007 / Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine / N Engl J Med 357:1810~1820
Noh SH / 2014 / Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC):5-year follow-up of an open-label, randomised phase 3 trial / Lancet Oncol 15:1389~1396
Koizumi W / 2008 / S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial / Lancet Oncol 9:215~221
Kang YK / 2009 / Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial / Ann Oncol 20:666~673
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Treatment Options for Advanced Gastric Cancer with Peritoneal Metastasis: Experience from a Single Institution in Korea
대한외과학회 학술대회 초록집
2020 .11
-
Efficacy of Treatment Options for Patients with Advanced Gastric Cancer And Severe Peritoneal Metastasis
대한외과학회 학술대회 초록집
2020 .11
-
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy as Treatment Options for Peritoneal Metastasis of Advanced Gastric Cancer
Journal of Gastric Cancer
2018 .09
-
Multicenter Retrospective Analysis of Intraperitoneal Paclitaxel and Systemic Chemotherapy for Advanced Gastric Cancer with Peritoneal Metastasis
Journal of Gastric Cancer
2020 .01
-
Gastric Cancer is a Peritoneal Disease
대한임상종양학회 학술대회지
2017 .02
-
Cytoreductive Surgery and Intra-Peritoneal Chemotherapy for Peritoneal Metastasis of Colorectal Cancer: Analysis of Prognostic Factors Related to Survival
대한외과학회 학술대회 초록집
2021 .05
-
Feasibility and Safety of Totally Laparoscopic Radical Gastrectomy for Advanced Gastric Cancer: Comparison with Early Gastric Cancer
Journal of Gastric Cancer
2018 .06
-
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy as Treatment Options for Peritoneal Metastasis of Advanced Gastric Cancer
대한외과학회 학술대회 초록집
2018 .11
-
The Result of Conversion Surgery in Gastric Cancer Patients with Peritoneal Seeding
대한임상종양학회 학술대회지
2016 .02
-
Potential for Peritoneal Metastasis after Gastric Perforation Induced by Endoscopic Submucosal Dissection of Early Gastric Cancer
Gut and Liver
2019 .01
-
Phase I Clinical Trial of Intraperitoneal Paclitaxel Combined with Systemic S-1 Plus Oxaliplatin for Advanced or Recurrent Gastric Cancer with Peritoneal Metastasis: The PIPS-GC trial
대한임상종양학회 학술대회지
2021 .06
-
Surgical Intervention for Liver Metastasis from Gastric Cancer
대한임상종양학회 학술대회지
2018 .02
-
항암화학요법과 한방치료를 병행하여 전환수술이 가능하게 호전된 진행성 위암 환자 1례
대한한방내과학회지
2020 .01
-
Treatment Outcomes and Survival Study of Gastric Cancer Patients: A Retrospective Analysis in an Endemic Region
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Recent Progress in Immunotherapy for Gastric Cancer
Journal of Gastric Cancer
2023 .01
-
Treatment Modality Based Survival in Gastric Carcinoma Patients with Stand-Alone Peritoneal Metastasis: a Case-Control Study
Journal of Gastric Cancer
2021 .01
-
Adequacies of lymphadenectomy range for gastric cancer according to the second and third/fourth Japanese gastric cancer treatment guidelines
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2017 .12
-
Update of Clinical Trials of Palliative Chemotherapy in Stomach Cancer
대한외과학회 학술대회 초록집
2021 .05
-
Peritoneal cancer index as a predictor of survival in advanced stage serous epithelial ovarian cancer: a prospective study
Journal of Gynecologic Oncology
2018 .01
-
Cytoreductive Surgery And Intra-peritoneal Chemotherapy for Peritoneal Metastasis of Colorectal Cancer: Long-term Follow up Results
대한외과학회 학술대회 초록집
2020 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2021-514-001697766