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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 179 - 179 (1page)
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Background/Aims
Breast cancer is a heterogeneous disease which presents diverse clinical, pathologic, and genetic characteristics. Through targeted next-generation sequencing (NGS), multiple genetic alterations of breast cancer can be identified. We aimed to elucidate the relationship between genetic alterations and clinical outcome of breast cancer.
Methods
We retrospectively reviewed electrical medical records of breast cancer patients who underwent surgical resection between 2018 and 2021. We collected clinicopathological characteristics of breast cancer patients whose NGS data were available. We performed survival analysis after excluding patients with recurrent breast cancer, initial metastatic disease, and those who underwent palliative resection.
Results
A total of 254 patients with NGS data were identified. Of the 50 genes included in the pan-cancer panel, 20 genes were significantly mutated. There were 220 nonsynonymous missense mutations, 71 frameshift mutations, 38 nonsense mutations, and 8 small indels. The most f ... 전체 초록 보기
Breast cancer is a heterogeneous disease which presents diverse clinical, pathologic, and genetic characteristics. Through targeted next-generation sequencing (NGS), multiple genetic alterations of breast cancer can be identified. We aimed to elucidate the relationship between genetic alterations and clinical outcome of breast cancer.
Methods
We retrospectively reviewed electrical medical records of breast cancer patients who underwent surgical resection between 2018 and 2021. We collected clinicopathological characteristics of breast cancer patients whose NGS data were available. We performed survival analysis after excluding patients with recurrent breast cancer, initial metastatic disease, and those who underwent palliative resection.
Results
A total of 254 patients with NGS data were identified. Of the 50 genes included in the pan-cancer panel, 20 genes were significantly mutated. There were 220 nonsynonymous missense mutations, 71 frameshift mutations, 38 nonsense mutations, and 8 small indels. The most f ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-514-001919556