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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 169 - 169 (1page)
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Background: The calvarial defects of the rat and rabbit are the most frequently used preclinical models for the evaluation of the bone regenerative potential of biomaterials. However, few studies have compared the two models. CCL5 is a periodontal specific chemokine that is known to induce bone regeneration. Aim: The aim of the present study is to compare the bone regenerative potential of CCL5 in the calvarial defects of rat and rabbit. Materials and Methods: Circular defects of 6 mm and 8 mm were created using trephine bur in calvarium of the rat and rabbit, respectively. The defects were randomly allocated to the three groups: (i) control (-) group having no treatment(n=8), (ii) control (+) group containing the collagen membrane(n=8), and (iii) the test group containing the collagen membrane loaded with CCL5(10ng/ml)(n=8). The samples were collected at 2 weeks postoperative. Histometric analysis was performed to measure the % of newly generated bone within each ... 전체 초록 보기
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