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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.3
- 수록면
- 21 - 28 (8page)
- DOI
- 10.21851/obr.46.01.202203.21
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초록· 키워드
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We evaluated the effects of lidocaine?maltodextrin?thrombin (LMT) collagen on new bone formation on a rat calvarial defect model.
Thirty-six rats were randomly divided into three groups. A single bone window was prepared in the middle of the calvarium, and each bone defect was treated separately. In Group 1, the bone defect was sutured without any treatment. In group 2, only the collagen plug was inserted into the bone defect, and in group 3, the collagen plug soaked with LMT collagen was inserted. After four weeks, six animals were sacrificed randomly in each group, and samples of the skull area were then collected and subjected to micro-computed tomography and hematoxylin and eosin and Masson’s trichrome staining. At eight weeks postsurgery, the remaining six rats in each group were treated identically. Consequently, no significant differences were noted in the bone formation between the groups at week 4. At week 8, a significant increase in new bone formation was observed in rats treated with collagen plug plus LMT collagen compared with untreated rats and rats treated only with the collagen plug. Therefore, the combination of LMT collagen and collagen plug is expected to function as an effective scaffold, which can provide clinicians with various possibilities and options for repairing bone defects.
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