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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 310 - 315 (6page)
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초록· 키워드
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Orostachys japonicus (O. japonicus) is known as a medicinal plant for the treatment of various symptoms. This study investigated the anti-inflammatory effect of the hexane fraction from O. japonicus (OJH) on the LPS-stimulated response in RAW 264.7 macrophage cells. This study was conducted to confirm the effect of cell cytotoxicity and production of reactive oxygen species (ROS) in OJH-treated macrophage cells. Additionally, pro-inflammatory cytokines and transcription factors were determined using RT-PCR and western blotting assay. OJH showed no change in lactate dehydrogenase (LDH) levels and exhibited reduced ROS levels in LPS-induced inflammatory cells. Moreover, OJH significantly suppressed the mRNA levels of proinflammatory cytokines, including IL-1β, IL-2, IL-6, TNF-α, and IP-10. Furthermore, OJH effectively inhibited the protein levels of AP-1 (p-c-Jun and p-c-Fos) and p-IRF3 in a dose-dependent manner. In conclusion, our results demonstrate that OJH exhibits strong anti-inflammatory activities via regulation of inflammatory factors.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
김진경 / 2015 / Licochalcone B Exhibits Anti-inflammatory Effects via Modulation of NF-κB and AP-1 / 대한의생명과학회지 21(4):218~226
Gilroy D / 2015 / New insights into the resolution of inflammation / Semin. Immunol 27:161~168
O’Neill LA / 2006 / How toll-like receptors signal : what we know and what we don’t know / Curr. Opin. Immunol 18:3~9
Fitzgerald KA / 2003 / IKK epsilon and TBK1 are essential components of the IRF3 signaling pathway / Nat. Immunol 4:491~496
정진부 / 2012 / Anti-Inflammatory Effects of Ethyl Acetate Fraction from Cnidium officinale Makino on LPS-Stimulated RAW 264.7 and THP-1 Cells / 한국자원식물학회지 25(3):299~307
Gilroy D / 2015 / New insights into the resolution of inflammation / Semin. Immunol 27:161~168
O’Neill LA / 2006 / How toll-like receptors signal : what we know and what we don’t know / Curr. Opin. Immunol 18:3~9
Fitzgerald KA / 2003 / IKK epsilon and TBK1 are essential components of the IRF3 signaling pathway / Nat. Immunol 4:491~496
정진부 / 2012 / Anti-Inflammatory Effects of Ethyl Acetate Fraction from Cnidium officinale Makino on LPS-Stimulated RAW 264.7 and THP-1 Cells / 한국자원식물학회지 25(3):299~307
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