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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제12호
- 발행연도
- 2020.1
- 수록면
- 1,835 - 1,842 (8page)
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Ergosterol, an essential constituent of membrane lipids of yeast, is distributed in both the cell membrane and intracellular endomembrane components such as vacuoles. Honokiol, a major polyphenol isolated from Magnolia officinalis, has been shown to inhibit the growth of Candida albicans. Here, we assessed the effect of honokiol on ergosterol biosynthesis and vacuole function in C. albicans. Honokiol could decrease the ergosterol content and upregulate the expression of genes related with the ergosterol biosynthesis pathway. The exogenous supply of ergosterol attenuated the toxicity of honokiol against C. albicans. Honokiol treatment could induce cytosolic acidification by blocking the activity of the plasma membrane Pma1p H+-ATPase. Furthermore, honokiol caused abnormalities in vacuole morphology and function. Concomitant ergosterol feeding to some extent restored the vacuolar morphology and the function of acidification in cells treated by honokiol. Honokiol also disrupted the intracellular calcium homeostasis. Amiodarone attenuated the antifungal effects of honokiol against C. albicans, probably due to the activation of the calcineurin signaling pathway which is involved in honokiol tolerance. In conclusion, this study demonstrated that honokiol could inhibit ergosterol biosynthesis and decrease Pma 1p H+ -ATPase activity, which resulted in the abnormal pH in vacuole and cytosol.
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참고문헌 (39)
참고문헌 신청
Rodrigues CF / 2019 / Candida sp. Infections in patients with diabetes mellitus / J. Clin. Med. 8:76
Da SDA / 2016 / Cell biology of Candida albicans-host interactions / Curr. Opin. Microbiol 34:111~118
Villasmil ML / 2020 / An Erg11 lanosterol 14-alpha-demethylase-Arv1complex is required for Candida albicans virulence / PLoS One 15:e235746
Kean R / 2019 / Combined antifungal resistance and biofilm tolerance : the global threat of Candida auris / mSphere 4:e00458
Sanguinetti M / 2005 / Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance / Antimicrob. Agents Chemother 49:668~679
Da SDA / 2016 / Cell biology of Candida albicans-host interactions / Curr. Opin. Microbiol 34:111~118
Villasmil ML / 2020 / An Erg11 lanosterol 14-alpha-demethylase-Arv1complex is required for Candida albicans virulence / PLoS One 15:e235746
Kean R / 2019 / Combined antifungal resistance and biofilm tolerance : the global threat of Candida auris / mSphere 4:e00458
Sanguinetti M / 2005 / Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance / Antimicrob. Agents Chemother 49:668~679
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