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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 190 - 196 (7page)
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Several factors, including genetic and environmental insults, impede protein folding and secretion in the endoplasmic reticulum (ER). Accumulation of unfolded or mis-folded protein in the ER manifests as ER stress. To cope with this morbid condition of the ER, recent data has suggested that the intracellular event of an unfolded protein response plays a critical role in managing the secretory load and maintaining proteostasis in the ER. Tauroursodeoxycholic acid (TUDCA) is a chemical chaperone and hydrophilic bile acid that is known to inhibit apoptosis by attenuating ER stress. Numerous studies have revealed that TUDCA affects hepatic diseases, obesity, and inflammatory illnesses. Recently, molecular regulation of ER stress in tooth development, especially during the secretory stage, has been studied. Therefore, in this study, we examined the developmental role of ER stress regulation in tooth morphogenesis using in vitro organ cultivation methods with a chemical chaperone treatment, TUDCA. Altered cellular events including proliferation, apoptosis, and dentinogenesis were examined using immunostaining and terminal deoxynucleotidyl transferase dUTP nick end labeling assay. In addition, altered localization patterns of the formation of hard tissue matrices related to molecules, including amelogenin and nestin, were examined to assess their morphological changes. Based on our findings, modulating the role of the chemical chaperone TUDCA in tooth morphogenesis, especially through the modulation of cellular proliferation and apoptosis, could be applied as a supporting data for tooth regeneration for future studies.
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참고문헌 (36)
참고문헌 신청
Markku Larmas / 2001 / Odontoblast Function Seen as the Response of Dentinal Tissue to Dental Caries / Advances in Dental Research 15(1):68~71
Nobuyuki Kawashima / 2016 / Odontoblasts: Specialized hard-tissue-forming cells in the dentin-pulp complex / Congenital Anomalies 56(4):144~153
Thimios Mitsiadis / 2009 / Odontoblasts in the dental pulp immune response / Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 312B(5):425~436
I Thesleff / 1999 / Molecular regulation of tooth development / Bone 25(1):123~125
Nanci A / 2017 / Ten Cate’s oral histology: development, structure, and function / Elsevier
Nobuyuki Kawashima / 2016 / Odontoblasts: Specialized hard-tissue-forming cells in the dentin-pulp complex / Congenital Anomalies 56(4):144~153
Thimios Mitsiadis / 2009 / Odontoblasts in the dental pulp immune response / Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 312B(5):425~436
I Thesleff / 1999 / Molecular regulation of tooth development / Bone 25(1):123~125
Nanci A / 2017 / Ten Cate’s oral histology: development, structure, and function / Elsevier
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