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논문 기본 정보

자료유형
학술저널
저자정보
Nagehan Can (Torbali State Hospital) Ercan Ozsoy (University of Health Sciences) Sabiha Gungor Kobat (University of Health Sciences) Elif Yusufoglu (University of Health Sciences) Nevin Ilhan (Firat University School of Medicine) Tamer Demir (Canakkale Onsekiz Mart University School of Medicine)
저널정보
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제34권 제5호
발행연도
2020.1
수록면
398 - 403 (6page)

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Purpose: To evaluate the concentration of serum cystatin C (CysC) in patients with Graves’ ophthalmopathy (GO) and the usabilityof the serum CysC concentrations in the follow-up of the disease. Methods: Thirty patients with GO and 30 healthy age-matched volunteers were included in this cross-sectional study. GOwas diagnosed based on the European Group on Graves’ Orbitopathy consensus. Serum thyroid-stimulating hormone, freetriiodothyronine, free thyroxine, and CysC concentrations were measured in the participants. The serum CysC concentrationswere compared between patients with GO and controls. Patients with GO were subdivided into hyperthyroid and euthyroidpatients, and their serum CysC concentrations were compared. In addition, the CysC concentrations in hyperthyroid and euthyroidpatients with GO were compared separately with those of healthy subjects. Kruskal-Wallis test and Student’s t-testwere used for statistical evaluation. Results: The mean serum CysC concentrations in GO patients and controls were 1.04 ± 0.36 and 0.74 ± 0.09 mg/L, respectively. There was a statistically significant difference in the serum CysC concentrations between patients with GO and control subjects (p< 0.001). Fifteen patients had hyperthyroid status, and 15 patients had euthyroid status. The mean serum CysC concentrationsin hyperthyroid and euthyroid patients with GO were 1.35 ± 0.22 and 0.72 ± 0.13 mg/L, respectively. Serum CysC concentrationswere significantly higher in hyperthyroid patients than in euthyroid patients (p = 0.001). In addition, hyperthyroid patients hadsignificantly higher serum CysC concentrations than healthy subjects. Among patients with GO, 21 and nine had mild and moderate-to-severe GO, respectively. Active and inactive GO were observed in eight and 22 patients, respectively. Conclusions: The serum CysC concentrations in hyperthyroid patients were higher than those in healthy subjects. Moreover,hyperthyroid patients had higher serum CysC concentrations than euthyroid patients. Further studies with a larger samplesize are needed to confirm these results.
#Cystatin C #Exophthalmos #Serum #Thyroxine #Triiodothyronine

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참고문헌 (21)

참고문헌 신청
Jinguji M / 2017 / Thymic involution after radioiodine therapy for Graves disease : relationships with serum thyroid hormones and TRAb / J Endocr Soc 1:852~860 google schola Kamboj A / 2017 / Ophthalmic manifestations of endocrine disorders-endocrinology and the eye / Transl Pediatr 6:286~299 google schola Xiong H / 2016 / Genetic associations of the thyroid stimulating hormone receptor gene with Graves diseases and Graves ophthalmopathy : a meta-analysis / Sci Rep 6:30356 google schola Xia N / 2017 / Simultaneous induction of Graves’ hyperthyroidism and Graves’ ophthalmopathy by TSHR genetic immunization in BALB/c mice / PLoS One 12:e0174260 google schola Xu L / 2017 / Thickness of extraocular muscle and orbital fat in MRI predicts response to glucocorticoid therapy in Graves’ ophthalmopathy / Int J Endocrinol 2017:3196059 google schola

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