지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,153 - 1,161 (9page)
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초록· 키워드
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Purpose High microsatellite instability (MSI) is related to good prognosis in gastric cancer. We aimed to identify the prognostic factors of patients with recurrent gastric cancer and investigate the role of MSI as a prognostic and predictive biomarker of survival after tumor recurrence. Materials and Methods This retrospective cohort study enrolled patients treated for stage II/III gastric cancer who developed tumor recurrence and in whom the MSI status or mismatch repair (MMR) status of the tumor was known. MSI status and the expression of MMR proteins were evaluated using polymerase chain reaction and immunohistochemical analysis, respectively. Results Of the 790 patients included, 64 (8.1%) had high MSI status or MMR deficiency. The tumor-node-metastasis stage, type of recurrence, Lauren classification, chemotherapy after recurrence, and interval to recurrence were independently associated with survival after tumor recurrence. The MSI/MMR status and receiving adjuvant chemotherapy were not associated with survival after recurrence. In a subgroup analysis of patients with high MSI or MMR-deficient gastric cancer, those who did not receive adjuvant chemotherapy had better treatment response to chemotherapy after recurrence than those who received adjuvant chemotherapy. Conclusion Patients with high MSI/MMR-deficient gastric cancer should be spared from adjuvant chemotherapy after surgery, but aggressive chemotherapy after recurrence should be considered. Higher tumor-node-metastasis stage, Lauren classification, interval to recurrence, and type of recurrence are associated with survival after tumor recurrence and should thus be considered when establishing a treatment plan and designing clinical trials targeting recurrent gastric cancer.
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참고문헌 (30)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
정규원 / 2019 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2016 / Cancer Research and Treatment 51(2):417~430
Noh SH / 2014 / Adjuvant capecitabine plus oxaliplatin for gastric can-cer after D2 gastrectomy(CLASSIC) : 5-year follow-up of an open-label, randomised phase 3 trial / Lancet Oncol 15:1389~1396
Pietrantonio F / 2019 / Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer / J Clin Oncol 37:3392~3400
Ito S / 2018 / Survival after recurrence in patients with gastric cancer who receive S-1 adjuvant chemotherapy : exploratory analysis of the ACTS-GC trial / BMC Cancer 18:449
정규원 / 2019 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2016 / Cancer Research and Treatment 51(2):417~430
Noh SH / 2014 / Adjuvant capecitabine plus oxaliplatin for gastric can-cer after D2 gastrectomy(CLASSIC) : 5-year follow-up of an open-label, randomised phase 3 trial / Lancet Oncol 15:1389~1396
Pietrantonio F / 2019 / Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer / J Clin Oncol 37:3392~3400
Ito S / 2018 / Survival after recurrence in patients with gastric cancer who receive S-1 adjuvant chemotherapy : exploratory analysis of the ACTS-GC trial / BMC Cancer 18:449
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