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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제6호
- 발행연도
- 2020.1
- 수록면
- 593 - 602 (10page)
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초록· 키워드
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Purpose The purpose of this study to establish the safety and efficacy data of Bojungikgi-tang (BJIGT) soft extract by determining the clinical pharmacokinetics (PKs) of its main ingredients and their active metabolites after oral administration. Methods A randomized, open-label, single-dose, single-center study on 12 healthy Korean male subjects was conducted. The plasma concentration of the active ingredients in BJIGT soft extract was determined in UPLC-MS/MS. Phoenix Win- Nonlin (version 8.1, Pharsight ®, a Certara™ Company, Princeton, NJ, USA) was used to conduct compartmental and noncompartmental (NCA) analyses to assess PK parameters. Results The PK parameters of ginsenoside Rb1 (Rb1) and glycyrrhizin (GL) were well described with 1-compartment analysis without lag time, and the 1-compartment model with combined transit compartment model and first-order absorption was used to evaluate the parameters of glycyrrhetinic acid (GLA). PK parameters of Rb1, GL and GLA including the clearance (CL/F), the volume of distribution (V/F), the rate of absorption ( Ka), the maximum concentration ( Cmax), time to reach maximum concentration ( Tmax), the area under the curve of a plasma concentration versus time profile (AUC 0-inf), and the elimination half-life ( T1/2) were successfully estimated. Conclusion This is the first report to evaluate the PKs of major active ingredients and their metabolites after oral administration of BJIGT soft extract to Korean subjects.
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참고문헌 (24)
참고문헌 신청
Alolga RN / 2015 / Pharmacokinetics of a multicomponent herbal preparation in healthy Chinese and African volunteers / Sci Rep 5:12961
Bhagwat S / USDA database for the flavonoid content of selected foods. Release 3.2
변종찬 / 2019 / Recent formulation approaches to oral delivery of herbal medicines / Journal of Pharmaceutical Investigation 49(1):17~26
Min-Koo Choi / 2020 / Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human beings / Journal of Ginseng Research 44(2):229~237
Erlund I / 2002 / Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables / Eur J Clin Nutr 56(9):891~898
Bhagwat S / USDA database for the flavonoid content of selected foods. Release 3.2
변종찬 / 2019 / Recent formulation approaches to oral delivery of herbal medicines / Journal of Pharmaceutical Investigation 49(1):17~26
Min-Koo Choi / 2020 / Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human beings / Journal of Ginseng Research 44(2):229~237
Erlund I / 2002 / Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables / Eur J Clin Nutr 56(9):891~898
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