지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Although estrogen-progestin therapy has traditionally been standard care for postmenopausal women with an intact uterus experiencing bothersome menopausal symptoms, concerns about side effects related to menopausal hormone therapy (MHT) have led to a dramatic decrease in MHT use over recent decades. As many MHT side effects are now believed to be associated with the progestin component of MHT, efforts have been made to develop a progestin-free alternative to conventional MHT. Recently, a tissue-selective estrogen complex (TSEC), a combination of conjugated estrogen and bazedoxifene, was developed as a progestin-free MHT and is now approved and used worldwide for the relief of vasomotor symptoms and the prevention of bone loss in postmenopausal women. Replacement of synthetic progestin with bazedoxifene could allow more favorable safety profiles, such as those for pain or tenderness, mammographic density, and cancer incidence, for the breast. This review examined the effects of the TSEC on breasts and demonstrated evidence from preclinical and clinical studies supporting TSEC use in clinical practice.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
The NAMS 2017 Hormone Therapy Position Statement Advisory Panel / 2017 / The 2017 hormone therapy position statement of The North American Menopause Society / Menopause 24:728~753
Rossouw JE / 2002 / Risks and benefits of estrogen plus progestin in healthy postmenopausal women : principal results from the Women's Health Initiative randomized controlled trial / JAMA 288:321~333
Anderson GL / 2004 / Effects of conjugated equine estrogen in postmenopausal women with hysterectomy : the Women's Health Initiative randomized controlled trial / JAMA 291:1701~1712
Peano BJ / 2009 / Effects of various selective estrogen receptor modulators with or without conjugated estrogens on mouse mammary gland / Endocrinology 150:1897~1903
Song Y / 2012 / Effects of the conjugated equine estrogen/bazedoxifene tissue-selective estrogen complex(TSEC)on mammary gland and breast cancer in mice / Endocrinology 153:5706~5715
Rossouw JE / 2002 / Risks and benefits of estrogen plus progestin in healthy postmenopausal women : principal results from the Women's Health Initiative randomized controlled trial / JAMA 288:321~333
Anderson GL / 2004 / Effects of conjugated equine estrogen in postmenopausal women with hysterectomy : the Women's Health Initiative randomized controlled trial / JAMA 291:1701~1712
Peano BJ / 2009 / Effects of various selective estrogen receptor modulators with or without conjugated estrogens on mouse mammary gland / Endocrinology 150:1897~1903
Song Y / 2012 / Effects of the conjugated equine estrogen/bazedoxifene tissue-selective estrogen complex(TSEC)on mammary gland and breast cancer in mice / Endocrinology 153:5706~5715
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