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논문 기본 정보

자료유형
학술저널
저자정보
Ara Cho (National Institute of Animal Science RDA Wanju) Sang-Ik Oh (National Institute of Animal Science RDA Wanju) Changyong Choe (National Institute of Animal Science RDA Wanju) Young-Hun Jung (National Institute of Animal Science RDA Wanju) Yoon Jung Do (National Institute of Animal Science RDA Wanju) Suhee Kim (National Institute of Animal Science RDA Wanju) Hyun Wook Choo (LABnPEOPLE Co. Ltd. Yangju) Jong Su Gu (LABnPEOPLE Co. Ltd. Yangju) Woo-Jin Chung (LABnPEOPLE Co. Ltd. Yangju) Sung Youn Cho (LABnPEOPLE Co. Ltd. Yangju) Jae Gyu Yoo (National Institute of Animal Science RDA Wanju)
저널정보
한국동물위생학회(구 한국가축위생학회) 한국가축위생학회지 한국가축위생학회지 제43권 제3호
발행연도
2020.1
수록면
129 - 137 (9page)

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In this study, we applied biodegradable drug delivery carries (BDDC) for food-and-mouth (FMD) vaccination. After FMD vaccination using BDDC, we estimated the percentage inhibition (PI) of antibody, decomposed patterns, and histopathologic features of BDDC. PI of antibody was higher than 50 at two weeks after injection and sustained positive PI until 10 weeks after injection. BBDC injection group showed significantly an increased pattern of blood monocyte at two and three weeks after injection. According to the Micro CT, micro-cracks were observed at two weeks after injection and the morphology of BDDC was lost at four weeks after injection. For histopathological examination, acute inflammation with neutrophil infiltration and micro-metallic residues were observed around BDDC until four weeks after injection and inflammatory responses gradually decreased at 10 weeks. Based on our experiment, BDDC is considered as an alternative way to vaccine injection for veterinary applications. Our study can be used as basic data for the drug delivery system using biodegradable metals in the future.

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