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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 461 - 475 (15page)
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초록· 키워드
오류제보하기
Despite more than two decades of extensive research focusing on nonalcoholic fatty liver disease (NAFLD), no approved therapy for steatohepatitis?the severe histological form of the disease?presently exists. More importantly, new drugs and small molecules with diverse molecular targets on the pathways of hepatocyte injury, inflammation, and fibrosis cannot achieve the primary efficacy endpoints. Precision medicine can potentially overcome this issue, as it is founded on extensive knowledge of the druggable genome/proteome. Hence, this review summarizes significant trends and developments in precision medicine with a particular focus on new potential therapeutic discoveries modeled via systems biology approaches. In addition, we computed and simulated the potential utility of the NAFLD polygenic risk score, which could be conceptually very advantageous not only for early disease detection but also for implementing actionable measures. Incomplete knowledge of the druggable NAFLD genome severely impedes the drug discovery process and limits the likelihood of identifying robust and safe drug candidates. Thus, we close this article with some insights into emerging disciplines, such as chemical genetics, that may accelerate accurate identification of the druggable NAFLD genome/proteome.
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등록된 정보가 없습니다.
참고문헌 (59)
참고문헌 신청
Brunt EM / 2015 / Nonalcoholic fatty liver disease / Nat Rev Dis Primers 1:15080
Pirola CJ / 2020 / Epigenetics factors in nonalcoholic fatty liver disease / Expert Rev Gastroenterol Hepatol
Sookoian S / 2017 / Genetic predisposition in nonalcoholic fatty liver disease / Clin Mol Hepatol 23:1~12
Sookoian S / 2019 / Genetics of nonalcoholic fatty liver disease : from pathogenesis to therapeutics / Semin Liver Dis 39:124~140
Chalasani N / 2020 / Effects of belapectin, an inhibitor of galectin-3, in patients with nonalcoholic steatohepatitis with cirrhosis and portal hypertension / Gastroenterology 158:1334~1345.e5
Pirola CJ / 2020 / Epigenetics factors in nonalcoholic fatty liver disease / Expert Rev Gastroenterol Hepatol
Sookoian S / 2017 / Genetic predisposition in nonalcoholic fatty liver disease / Clin Mol Hepatol 23:1~12
Sookoian S / 2019 / Genetics of nonalcoholic fatty liver disease : from pathogenesis to therapeutics / Semin Liver Dis 39:124~140
Chalasani N / 2020 / Effects of belapectin, an inhibitor of galectin-3, in patients with nonalcoholic steatohepatitis with cirrhosis and portal hypertension / Gastroenterology 158:1334~1345.e5
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