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자료유형
학술저널
저자정보
윤태준 (연세대학교) 안성수 (연세대학교) 송정식 (연세대학교) 박용범 (연세대학교) 이상원 (연세대학교)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제61권 제8호
발행연도
2020.1
수록면
720 - 725 (6page)

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Lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1) binds to oxidized LDL, which is associated with inflammationin various vascular disorders. Here, we aimed to investigate the potential of soluble LOX1 (sLOX1) as an indicator of antineutrophilcytoplasmic antibody-associated vasculitis (AAV) activity. Serum levels of sLOX1 in frozen samples from patients withAAV enrolled in a prospective observational cohort study at the Severance Hospital were measured using enzyme-linked immunosorbentassay. Clinical and laboratory data were collected on the date when the blood sampling was performed. The associationbetween sLOX1 and clinical and laboratory data was assessed using Pearson’s correlation analysis. The median age of the recruited79 patients was 62.0 years, and 27 (34.2%) patients were men. The median Birmingham vasculitis activity score (BVAS),five-factor score, vasculitis damage index, and sLOX1 level were 6, 1, 3, and 911.9 pg/mL, respectively. Correlation analysis basedon BVAS revealed that sLOX1 and total cholesterol were significantly inversely correlated with BVAS (r=-0.224, p=0.047 and r=-0.424, p<0.001, respectively). No significant correlations were observed between continuous variables and sLOX1 except forBVAS, although total cholesterol tended to correlate with sLOX1 (r=0.190, p=0.093). Additionally, sLOX1 was not influenced by sex,hypertension, diabetes mellitus, or the presence of pulmonary, cardiovascular, and renal involvement of AAV. In summary, sLOX1was inversely correlated with BVAS in AAV patients, which is different from other vascular diseases or inflammatory diseases.

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