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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 362 - 379 (18page)
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Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor) are among the most important medications for treating patients with acute myocardial infarction (AMI). Herein, we review the clinical benefit and future scope of statin therapy in Korean patients with AMI from the experience of the Korea AMI Registry. Statins are effective and safe in AMI patients, even in those with very low low-density lipoprotein cholesterol (LDL-C). Peri-procedural statin treatment could reduce the incidence of early stent thrombosis in patients with AMI after percutaneous coronary intervention. Reduction of high sensitivity C-reactive protein levels in patients with AMI plays an important role in the beneficial effect of statins on regression and compositional change of coronary plaques. Obtaining ≥50% reduction in LDL-C is associated with better clinical outcomes after AMI, whereas achieving <70 mg/dL LDL-C is not. Statin therapy has positive effects on clinical outcomes in patients with cardiogenic shock, ischemic heart failure, chronic kidney disease, and vasospasm. The combination of high-dose statin plus N-acetyl cysteine is associated with lower incidence of contrast-induced nephropathy in patients who underwent primary percutaneous coronary intervention. Moderate-intensity pitavastatin therapy is associated with a lower incidence of new-onset diabetes mellitus in patients with AMI and has similar clinical outcomes to moderate-intensity atorvastatin and rosuvastatin therapy. Future studies are required to assess the optimal intensity and LDL-C target concerning statin therapy, and the implementation of guidelines based cholesterol lowering practice in Korean patients with AMI.
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참고문헌 (43)
참고문헌 신청
이기홍 / 2013 / New Horizons of Acute Myocardial Infarction: From the Korea Acute Myocardial Infarction Registry / Journal of Korean Medical Science 28(2):173~180
김현국 / 2014 / The scientific achievements of the decades in Korean Acute Myocardial Infarction Registry / The Korean Journal of Internal Medicine 29(6):703~712
심두선 / 2017 / Differences in the Korea Acute Myocardial Infarction Registry Compared with Western Registries / Korean Circulation Journal 47(6):811~822
김용철 / 2019 / Current status of acute myocardial infarction in Korea / The Korean Journal of Internal Medicine 34(1):1~10
Kim HK / 2011 / Hospital discharge risk score system for the assessment of clinical outcomes in patients with acute myocardial infarction(Korea Acute Myocardial Infarction Registry [KAMIR] score) / Am J Cardiol 107:965~971
김현국 / 2014 / The scientific achievements of the decades in Korean Acute Myocardial Infarction Registry / The Korean Journal of Internal Medicine 29(6):703~712
심두선 / 2017 / Differences in the Korea Acute Myocardial Infarction Registry Compared with Western Registries / Korean Circulation Journal 47(6):811~822
김용철 / 2019 / Current status of acute myocardial infarction in Korea / The Korean Journal of Internal Medicine 34(1):1~10
Kim HK / 2011 / Hospital discharge risk score system for the assessment of clinical outcomes in patients with acute myocardial infarction(Korea Acute Myocardial Infarction Registry [KAMIR] score) / Am J Cardiol 107:965~971
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