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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 291 - 302 (12page)
- DOI
- 10.12997/jla.2021.10.3.291
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초록· 키워드
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Objective: We compared the effects of high-intensity statin monotherapy versus moderateintensity statin and ezetimibe combination therapy on major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI).
Methods: Using the Korean National Health Insurance Service database, we screened 82,941 patients with AMI who underwent percutaneous coronary intervention (PCI) between 2013 and 2016. Among them, we identified 9,908 patients treated with atorvastatin 40 mg (A40, n=4,041), atorvastatin 20 mg + ezetimibe 10 mg (A20+E10, n=233), rosuvastatin 20 mg (R20, n=5,251), or rosuvastatin 10 mg + ezetimibe 10 mg (R10+E10, n=383). The primary outcome was MACE, a composite of all-cause death, non-fatal myocardial infarction undergoing PCI, repeat revascularization, and ischemic stroke. Multivariable analyses were performed using the inverse probability of treatment weighting method.
Results: The incidence rate of MACE in the overall population was 42.97 cases per 1,000 person-years. There was no significant difference in the risk of composite outcomes of MACE between the groups. However, the R10+E10 group showed a higher risk of all-cause death (hazard ratio, 2.07; 95% confidence interval, 1.08?3.94) than the A40 group (reference group) in the weighted multivariable model.
Conclusions: In this study, there was no significant difference in the composite outcome of MACE between high-intensity statin monotherapy and moderate-intensity statin and ezetimibe combination therapy.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Grundy SM / 2019 / 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol : executive summary : a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines / J Am Coll Cardiol 73:3168~3209
Mach F / 2020 / 2019 ESC/EAS Guidelines for the management of dyslipidaemias : lipid modification to reduce cardiovascular risk / Eur Heart J 41:111~188
Cholesterol Treatment Trialists'(CTT)Collaboration / 2010 / Efficacy and safety of more intensive lowering of LDL cholesterol : a meta-analysis of data from 170, 000 participants in 26 randomised trials / Lancet 376:1670~1681
Waters DD / 2009 / Lipid treatment assessment project 2 : a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals / Circulation 120:28~34
Dujovne CA / 2011 / What combination therapy with a statin, if any, would you recommend? / Curr Atheroscler Rep 13:12~22
Mach F / 2020 / 2019 ESC/EAS Guidelines for the management of dyslipidaemias : lipid modification to reduce cardiovascular risk / Eur Heart J 41:111~188
Cholesterol Treatment Trialists'(CTT)Collaboration / 2010 / Efficacy and safety of more intensive lowering of LDL cholesterol : a meta-analysis of data from 170, 000 participants in 26 randomised trials / Lancet 376:1670~1681
Waters DD / 2009 / Lipid treatment assessment project 2 : a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals / Circulation 120:28~34
Dujovne CA / 2011 / What combination therapy with a statin, if any, would you recommend? / Curr Atheroscler Rep 13:12~22
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