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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 183 - 191 (9page)
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초록· 키워드
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Dyslipidemia, highly elevated, low-density lipoprotein (LDL) cholesterol, is a major cardiovascular risk factor. Statins have been proven to effectively reduce the risk of atherosclerotic cardiovascular disease (ASCVD) and are recommended as a first-line therapy for the primary and secondary prevention of ASCVD. However, statins may not be sufficient in decreasing LDL cholesterol levels and pose a significant on-treatment residual risk of major cardiovascular events (i.e., residual cholesterol risk) according to meta-analyses of statin trials. Current guidelines for cholesterol management to achieve additional LDL cholesterol reduction and reduce ASCVD risk recommend two hyperlipidemic agents besides statins. Use of ezetimibe, a cholesterol absorption inhibitor, leads to additional LCL cholesterol reduction and decreased ASCVD risk, when added to statin therapy, without raising significant safety concerns. Furthermore, in combination with a mild-to-moderate statin intensity, ezetimibe is used in situations of statin-associated adverse effects such as myalgia and the combination therapy is relatively safer. Monoclonal antibody of proprotein convertase subtilisin/kexin type 9 (PCSK9), alirocumab, and evolocumab, have been approved to lower LDL cholesterol level. While there are drawbacks to the use of PCSK9 inhibitors, including high cost and adverse events such as injection site reaction, they significantly decreased serum LDL cholesterol levels and thereby ASCVD risks when added to maximally tolerated statin therapy.
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등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Baigent C / 2010 / Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials / Lancet 376:1670~1681
Roth GA / 2015 / Global and regional patterns in cardiovascular mortality from 1990 to 2013 / Circulation 132:1667~1678
안창호 / 2015 / New Drugs for Treating Dyslipidemia: Beyond Statins / Diabetes and Metabolism Journal 39(2):87~94
Grundy SM / 2019 / 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol:a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines / J Am Coll Cardiol 73:e285~e350
Catapano AL / 2016 / 2016 ESC/EAS Guidelines for the management of dyslipidaemias / Eur Heart J 37:2999~3058
Roth GA / 2015 / Global and regional patterns in cardiovascular mortality from 1990 to 2013 / Circulation 132:1667~1678
안창호 / 2015 / New Drugs for Treating Dyslipidemia: Beyond Statins / Diabetes and Metabolism Journal 39(2):87~94
Grundy SM / 2019 / 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol:a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines / J Am Coll Cardiol 73:e285~e350
Catapano AL / 2016 / 2016 ESC/EAS Guidelines for the management of dyslipidaemias / Eur Heart J 37:2999~3058
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