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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 173 - 182 (10page)
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초록· 키워드
오류제보하기
Serum cholesterol is major risk factor and contributor to atherosclerotic cardiovascular disease (ASCVD). Therapeutic cholesterol-lowering drugs, especially statin, revealed that reduction in low-density lipoprotein cholesterol (LDL-C) produces marked reduction of ASCVD events. In the preventive scope, lower LDL-C is generally accepted as better in proven ASCVD patients and high-risk patient groups. However, in patients with low to intermediate risk without ASCVD, risk assessment is clinically guided by traditional major risk factors. In this group, the complement approach to detailed risk assessment about traditional major risk factors is needed. These non-traditional risk factors include ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP) level, lipoprotein(a) (Lp[a]), apolipoprotein B (apoB), or coronary artery calcium (CAC) score. CAC measurements have an additive role in the decision to use statin therapy in non-diabetic patients 40–75 years old with intermediate risk in primary prevention. This review comprises ASCVD lipid/biomarkers other than CAC. The 2013 and 2018 American College of Cardiology/American Heart Association (ACC/AHA) guidelines suggest these factors as risk-enhancing factors to help health care providers better determine individualized risk and treatment options especially regarding abnormal biomarkers. The recent 2018 Korean guidelines for management of dyslipidemia did not include these biomarkers in clinical decision making. The current review describes the current roles of hsCRP, ABI, LP(a), and apoB in personal modulation and management of health based on the 2018 ACC/AHA guideline on the management of blood cholesterol.
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참고문헌 (44)
참고문헌 신청
Stamler J / 1986 / Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT) / JAMA 256:2823~2828
Kannel WB / 1971 / Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study / Ann Intern Med 74:1~12
Boekholdt SM / 2014 / Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials / J Am Coll Cardiol 64:485~494
Cannon CP / 2015 / Ezetimibe added to statin therapy after acute coronary syndromes / N Engl J Med 372:2387~2397
Sabatine MS / 2017 / Evolocumab and clinical outcomes in patients with cardiovascular disease / N Engl J Med 376:1713~1722
Kannel WB / 1971 / Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study / Ann Intern Med 74:1~12
Boekholdt SM / 2014 / Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials / J Am Coll Cardiol 64:485~494
Cannon CP / 2015 / Ezetimibe added to statin therapy after acute coronary syndromes / N Engl J Med 372:2387~2397
Sabatine MS / 2017 / Evolocumab and clinical outcomes in patients with cardiovascular disease / N Engl J Med 376:1713~1722
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