Associations of LDL Cholesterol, Non-HDL Cholesterol, and Apolipoprotein B With Cardiovascular Disease Occurrence in Adults: Korean Genome and Epidemiology Study

Yun Shin Young; Rim John Hoon; Kang Hyein; Lee Sang-Guk; Lim Jong-Baeck

doi:10.3343/alm.2023.43.3.237

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자료유형: 학술저널

저자정보: Yun Shin Young (Department of Laboratory Medicine Yonsei University College of Medicine Seoul Korea) Rim John Hoon (Department of Laboratory Medicine Yonsei University College of Medicine Seoul Korea) Kang Hyein (Department of Laboratory Medicine Yonsei University College of Medicine Seoul Korea) Lee Sang-Guk (Department of Laboratory Medicine Yonsei University College of Medicine Seoul Korea) Lim Jong-Baeck (Department of Laboratory Medicine Yonsei University College of Medicine Seoul Korea)

저널정보: 대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제43권 제3호

발행연도: 2023.5

수록면: 237 - 243 (7page)

DOI: 10.3343/alm.2023.43.3.237

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Background: Despite the superiority of non-HDL cholesterol (non-HDL-C) and apolipoprotein B (ApoB) as lipid markers for atherosclerotic cardiovascular disease (ASCVD), these are only suitable as secondary markers. We compared LDL cholesterol (LDL-C), non-HDL-C, and ApoB concentrations with respect to the occurrence of cardiovascular disease in adults enrolled in the Korean Genome and Epidemiology Study (KoGES). Methods: We used information on age; sex; medical history; family history of ASCVD; current lipid-lowering therapy; current smoking status; and creatinine, total cholesterol, HDL-C, LDL-C, triglyceride, and ApoB concentrations from 5,872 KoGES participants without ASCVD. New ASCVD development was monitored during the 8-year follow-up period. Adjusted hazard ratios (aHRs) for ASCVD of LDL-C, non-HDL-C, and ApoB concentrations were calculated based on the multivariate Cox regression analyses. The participants were also grouped as low and high according to the median values for each lipid marker, and calculated aHRs of each group combined by two lipid makers. Results: ApoB showed the highest aHR per 1-SD for ASCVD (1.26; 95% confidence interval [CI], 1.11–1.43), followed by non-HDL-C (1.25; 95% CI, 1.11–1.41) and LDL-C (1.20; 95% CI, 1.06–1.37). The group with low LDL-C and high ApoB concentrations had a significantly higher aHR for ASCVD (1.61; 95% CI, 1.05–2.48) compared to the reference group values (low LDL-C and low ApoB concentrations). The aHR for the group with high LDL-C and low ApoB concentrations was not significant (1.30; 95% CI, 0.79–2.16). Conclusions: ApoB, non-HDL-C, and LDL-C are independent risk factors for ASCVD. Increases in the aHR per 1-SD for ASCVD were more strongly affected by ApoB, followed by non-HDL-C and LDL-C. Participants with low LDL-C and high ApoB concentrations showed increased ASCVD risk. For individuals with ASCVD risk factors, even those presenting normal LDL-C concentrations, measuring Apo

#Atherosclerosis #LDL #Cholesterol #Apolipoprotein B

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