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논문 기본 정보

자료유형
학술저널
저자정보
Hansol Choi (Yonsei University College of Medicine) Jee-Seon Shim (Yonsei University College of Medicine) Myung Ha Lee (Yonsei University College of Medicine) Young Mi Yoon (Yonsei University College of Medicine) Dong Phil Choi (Yonsei University College of Medicine) 김현창 (Yonsei University College of Medicine)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.46 No.5
발행연도
2016.1
수록면
688 - 698 (11page)

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Background and Objcetives: Low-density lipoprotein cholesterol (LDL-C), an established cardiovascular risk factor, can be generally determined by calculation from total cholesterol, high-density lipoprotein cholesterol, and triglyceride concentrations. The aim of this study was to compare LDL-C estimations using various formulas with directly measured LDL-C in a community-based group and hospital-based group among the Korean population. Subjects and Methods: A total of 1498 participants were classified into four groups according to triglyceride concentrations as follows: <100, 100–199, 200–299, and ≥300 mg/dL. LDL-C was calculated using the Friedewald, Chen, Vujovic, Hattori, de Cordova, and Anandaraja formulas and directly measured using a homogenous enzymatic method. Pearson’s correlation coefficients, intraclass correlation coefficients (ICC), Passing & Bablok regression, and Bland-Altman plots were used to evaluate the performance of six formulas. Results: The Friedewald formula had the highest accuracy (ICC=0.977; 95% confidence interval 0.974-0.979) of all the triglyceride ranges, while the Vujovic formula had the highest accuracy (ICC=0.876; 98.75% confidence interval 0.668–0.951) in people with triglycerides ≥300 mg/dL. The mean difference was the lowest for the Friedewald formula (0.5 mg/dL) and the percentage error was the lowest for the Vujovic formula (30.2%). However, underestimation of the LDL-C formulas increased with triglyceride concentrations. Conclusion: The accuracy of the LDL-C formulas varied considerably with differences in triglyceride concentrations. The Friedewald formula outperformed other formulas for estimating LDL-C against a direct measurement and the Vujovic formula was suitable for hypertriglyceridemic samples; it could be used as an alternative cost-effective tool to measure LDL-C when the direct measurement cannot be afforded.

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참고문헌 (27)

참고문헌 신청
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults / 2001 / Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on Detection, Evaluation, and Treatment of high blood cholesterol in adults (Adult Treatment Panel III) / JAMA 285:2486~2497 google schola European Association for Cardiovascular Prevention & Rehabilitation1 / 2011 / ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) / Eur Heart J 32:1769~1818 google schola Son JI / 2012 / Treatment guidelines for dyslipidemia:summary of the expanded second version / J Lipid Atheroscler 1:45~59 google schola Bachorik PS / 1995 / National Cholesterol Education Program recommendations for measurement of low-density lipoprotein cholesterol: executive summary. The National Cholesterol Education Program Working Group on Lipoprotein Measurement / Clin Chem 41:1414~1420 google schola Anandaraja S / 2005 / Lowdensity lipoprotein cholesterol estimation by a new formula in Indian population / Int J Cardiol 102:117~120 google schola

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