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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 80 - 86 (7page)
이용수
초록· 키워드
오류제보하기
Background and Purpose Low-density lipoprotein (LDL) particle size is considered to beone of the more important cardiovascular risk factors, and small LDL particles are known tohave atherogenic potential. The aim of this study was to determine whether LDL particle size isassociated with stroke severity and functional outcome in patients with atherothromboticstroke.
Methods Between January 2009 and May 2011, 248 patients with first-episode cerebral infarction who were admitted to our hospital within 7 days after symptom onset were prospectively enrolled. LDL particle size was measured using the nondenaturing polyacrylamide gradient gel electrophoresis assay. Stroke severity was assessed by applying the National Institutesof Health Stroke Scale (NIHSS) at admission. Functional outcome was investigated at 3months after the index stroke using the modified Rankin Scale (mRS), and poor functional outcome was defined as an mRS score of ≥3.
Results The LDL particle size in the 248 patients was 25.9±0.9 nm (mean±SD). LDL particle size was inversely correlated with the degree of cerebral artery stenosis (p=0.010). Multinomial multivariate logistic analysis revealed that after adjustment for age, sex, and variables withp<0.1 in univariate analysis, LDL particle size was independently and inversely associated withstroke severity (NIHSS score ≥5; reference, NIHSS score 0–2; odds ratio=0.38, p=0.028) andpoor functional outcome (odds ratio=0.44, p=0.038).
Conclusions The results of this study demonstrate that small LDL particles are independently correlated with stroke outcomes. LDL particle size is thus a potential biomarker for the prognosis of atherothrombotic stroke.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ 1991 / North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid s
/ 2002 / National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). T
/ 2003 / Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Trial Investigators. Design, progress and challenges of a double-blind trial of warfarin versus aspirin fo
Adams HP Jr / 1993 / Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treat
Barbagallo CM / 2002 / Changes in plasma lipids and low-density lipoprotein peak particle size during and after acute myocardial infarction / Am J Cardiol 89 : 460 ~ 462
/ 2002 / National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). T
/ 2003 / Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Trial Investigators. Design, progress and challenges of a double-blind trial of warfarin versus aspirin fo
Adams HP Jr / 1993 / Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treat
Barbagallo CM / 2002 / Changes in plasma lipids and low-density lipoprotein peak particle size during and after acute myocardial infarction / Am J Cardiol 89 : 460 ~ 462
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